TELIK ANNOUNCES EXPANSION OF PHASE 2 TRIAL OF TELCYTA IN
HEMATOLOGIC MALIGNANCIES

Palo Alto, CA - February 21, 2012 - Telik, Inc. (Nasdaq: TELK) today announced that the Phase 2 investigator-led Telcyta trial in hematologic malignancies has been expanded to an additional investigational site, Memorial Sloan-Kettering Cancer Center (MSKCC).  Based upon the results observed in Stage 1 of the trial, which is being conducted at the Robert Wood Johnson University Hospital under the direction of Joseph R. Bertino, MD of The Cancer Institute of New Jersey, an additional 10 patients with chemotherapy resistant multiple myeloma may be enrolled.  Additional trial investigators at MSKCC are Sergio A. Giralt, MD and Nikoletta Lendvai, MD, PhD.

About Telik

Telik, Inc. of Palo Alto, CA, is a clinical stage drug development company focused on discovering and developing small molecule drugs to treat cancer.  The company's most advanced drug candidate is Telintra®, a modified glutathione analog intended for the treatment of hematologic malignancies including myelodysplastic syndrome; followed by Telcyta®, a cancer activated prodrug for the treatment of a variety of cancers. Telik's product candidates were discovered using its proprietary drug discovery technology, TRAP®, which enables the rapid and efficient discovery of small molecule drug candidates.

Telik, the Telik logo, TELINTRA, TELCYTA and TRAP are trademarks or registered trademarks of Telik, Inc.

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Contact:
Denise San Bartolome
Corporate Communications
Telik, Inc.
Tel: 650 845 7712
Email: denisesb@telik.com