For immediate release

                                                                    21 October 2016

    THE BIOTECH GROWTH TRUST PLC

                                    (the "Company")                                

                        MARKET PURCHASE OF COMPANY'S OWN SHARES                    

    Notification is given, pursuant to the authority granted at the Annual General
    Meeting of the Company held 12 July 2016 to make market purchases of the
    Company's own shares up to an aggregate maximum of 8,754,920 that a market
    total of 86,989 Ordinary shares of 25p each in the capital of the Company were
    purchased on Friday, 21 October 2016 for cancellation by the Company at a price
    of 691.06 pence per share.

    Following this transaction and in conformity with the provisions of the
    Transparency Directive, the Company hereby notifies the market that the total
    number of Ordinary shares that the Company has in issue, less the total number
    of Ordinary shares bought back for cancellation by the Company following such
    purchase, and therefore, the total number of voting rights in the Company is
    56,397,708. The Company does not currently hold any Ordinary shares in
    treasury.

    The figure of 56,397,708 may be used by shareholders as the denominator for the
    calculation by which they may determine if they are required to notify their
    interest in, or change to their interest in, the Company under the FCA's
    Disclosure and Transparency Rules.

    For and on behalf of

    Frostrow Capital LLP

    Company Secretary

    For further information, please contact:

    Mark Pope

    Frostrow Capital LLP

    Tel: 020 3 170 4913