For immediate release

                                                                        27 May 2016

                             THE BIOTECH GROWTH TRUST PLC                          

                                    (the "Company")                                

                        MARKET PURCHASE OF COMPANY'S OWN SHARES                    

    Notification is given, pursuant to the authority granted at the Annual General
    Meeting of the Company held 8 July 2015 to make market purchases of the
    Company's own shares up to an aggregate maximum of 9,380,031 that a market
    total of 235,000 Ordinary shares of 25p each in the capital of the Company were
    purchased on Friday, 27 May 2016 for cancellation by the Company at a price of
    605.44 pence per share.

    Following this transaction and in conformity with the provisions of the
    Transparency Directive, the Company hereby notifies the market that; the total
    number of Ordinary shares that the Company has in issue, less the total number
    of Ordinary shares bought back for cancellation by the Company following such
    purchase, and therefore, the total number of voting rights in the Company is
    59,269,508. The Company does not currently hold any Ordinary shares in
    treasury.

    The figure of 59,269,508 may be used by shareholders as the denominator for the
    calculation by which they may determine if they are required to notify their
    interest in, or change to their interest in, the Company under the FCA's
    Disclosure and Transparency Rules.

    For and on behalf of
    Frostrow Capital LLP
    Company Secretary

    For further information, please contact:

    Mark Pope
    Frostrow Capital LLP
    Tel: 020 3 170 4913