• Five scientific presentations on romosozumab at ASBMR 2013
• Romosozumab is an investigational medicine in phase 3 clinical development for the treatment of osteoporosis in post-menopausal women

Brussels (Belgium), 4th October 2013 - (1730 CEST) - UCB, a global biopharmaceutical company is pleased to announce several scientific presentations on romosozumab at the annual meeting of the American Society for Bone and Mineral Research (ASBMR) 2013 in Baltimore, Maryland, US (October 4th-7th 2013). Romosozumab is an investigational medicine in phase 3 clinical development for the treatment of osteoporosis in post-menopausal women and is not currently approved by any regulatory authority.1,2

"The data presented for romosozumab at the ASBMR annual meeting illustrate UCB's commitment to the development of new treatments for people living with osteoporosis." said Professor Dr Iris Loew-Friedrich, Chief Medical Officer and Executive Vice President UCB.

UCB and Amgen are collaborating on the clinical development of romosozumab for the treatment of bone-related conditions.

Following is a guide to the presentations on romosozumab:

1. [1022] Effect of Romosozumab on Lumbar Spine and Hip Volumetric Bone Mineral Density (vBMD) as Assessed by Quantitative Computed Tomography (QCT)
Genant, H.K. et al.
Date/Time: Saturday, October 5th, 2013; 0915-0930
Session Info: Oral presentation

2. [SA0406] Bone Formation Response in Mice During Administration and Following
Re-challenge With an Antibody to Sclerostin
Robinson, M. et al.
Date/Time: Saturday, October 5th 2013; 1145-1150
Session Info: Oral Poster Presentations: Clinical
Date/Time: Saturday, October 5th 2013; 1200-1400
Session Info: Poster Session I & Poster Tours

3. [1069] Acute Increase in Bone Formation Following Sclerostin Antibody Treatment Is Consistent With Activation of Bone Lining Cells in Aged Ovariectomized Rats
Ominsky, M.S. et al.
Date/Time: Sunday, October 6th, 2013; 1600-1615
Session Info: Oral Presentation

4. [SU0411] Retreatment With Sclerostin Antibody Increased Bone Formation and Bone Mass in Ovariectomized Rats
Li, X . et al.
Date/Time: Sunday, October 6th, 2013; 1200-1400
Session Info: Poster Session II

5. [SU0412] Romosozumab (Sclerostin Antibody) Improves Bone Mass and Bone Strength in Ovariectomized Rats After 12 Months of Treatment
Ominsky, M. S. et al.
Date/Time: Sunday, October 6th, 2013; 1200-1400
Session Info: Poster Session II

Notes to Editors
About Osteoporosis3,4,5
Osteoporosis affects many women after menopause and is a disease that weakens bones over time, making them thinner and more likely to break. Post-menopausal women with osteoporosis have a greater risk for breaking a bone. Such a break, or fracture, may be a life-changing event. About one in three women over age 50 will have an osteoporosis-related fracture, and once that happens, the chances of another are much higher. The International Osteoporosis Foundation urges governments worldwide to make osteoporosis a healthcare priority.

About Romosozumab1,2
Romosozumab is a bone-forming agent that inhibits sclerostin. It is currently being studied for its potential to reduce fracture risk in an extensive global phase 3 program. This program includes two pivotal studies evaluating romosozumab against both placebo and active comparator in more than 10,000 women with post-menopausal osteoporosis. UCB and Amgen are collaborating on the development of romosozumab.

References
1. ClinicalTrials.gov Accessed September 2013 from http://clinicaltrials.gov/ct2/show/NCT01631214?term=Romosozumab&rank=
2. ClinicalTrials.gov Accessed September 2013 from http://clinicaltrials.gov/ct2/show/NCT01575834?term=AMG+785&rank=12
3. National Osteoporosis Foundation. "What is Osteoporosis." Accessed September 2013 from http://www.nof.org/articles/7.
4. International Osteoporosis Foundation." Facts and Statistics." Accessed September 2013 from http://www.iofbonehealth.org/facts-statistics#category-16.
5. International Osteoporosis Foundation. "Osteoporosis in the European Union in 2008: Ten years of progress and ongoing challenges." Accessed September 2013 from http://www.iofbonehealth.org/osteoporosis-european-union-ten-years-progress-and-ongoing-challenges

About UCB
UCB, Brussels, Belgium (www.ucb.com) is a global biopharmaceutical company focused on the discovery and development of innovative medicines and solutions to transform the lives of people living with severe diseases of the immune system or of the central nervous system. With 9000 people in approximately 40 countries, the company generated revenue of EUR 3.4 billion in 2012. UCB is listed on Euronext Brussels (symbol: UCB).

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PIPE-PRR-026057-102013

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