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SYSTEM RESEARCH : Researchers from Tokyo Medical and Dental University Detail New Studies and Findings in the Area of Neuroscience (Next-generation sequencing-based...

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01/19/2017 | 08:09pm CET

Researchers from Tokyo Medical and Dental University Detail New Studies and Findings in the Area of Neuroscience (Next-generation sequencing-based small RNA profiling of cerebrospinal fluid exosomes)

By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Current study results on Nervous System Research - Neuroscience have been published. According to news originating from value="LU/jp..tokyo" idsrc="xmltag.org">Tokyo, Japan, by NewsRx correspondents, research stated, "MicroRNAs (miRNAs), particularly those found in human body fluids, have been suggested as potential biomarkers. Among various body fluids, the cerebrospinal fluid (CSF) shows promise as a profiling target for diagnosis and monitoring of neurological diseases."

Our news journalists obtained a quote from the research from value="ACORN:3297817221" idsrc="xmltag.org">Tokyo Medical and Dental University, "However, relevant genome-scale studies are limited and no studies have profiled exosomal miRNAs in CSF. Therefore, we conducted a next-generation sequencing-based genome-wide survey of small RNAs in the exosomal and non-exosomal (supernatant) fractions of healthy human CSF as well as serum in each donor. We observed miRNA enrichment in the exosomal fractions relative to the supernatant fractions of both CSF and serum. We also observed substantial differences in exosomal miRNA profiles between CSF and serum. Half of the reported brain miRNAs were found in CSF exosomal fractions. In particular, miR-1911-5p, specifically expressed in brain tissue, was detected in CSF but not in serum, as confirmed by digital PCR in three additional donors. Our data suggest that the brain is a major source of CSF exosomal miRNAs."

According to the news editors, the research concluded: "Here we provide the important evidence that exosomal miRNAs in CSF may reflect brain pathophysiology."

For more information on this research see: Next-generation sequencing-based small RNA profiling of cerebrospinal fluid exosomes. style="i">Neuroscience Letters, 2017;636():48-57. style="i">Neuroscience Letters can be contacted at: value="ACORN:2171838658" idsrc="xmltag.org">Elsevier Ireland Ltd, Elsevier House, Brookvale Plaza, East Park Shannon, value="LU/ie..coclre" idsrc="xmltag.org">Co, Clare, 00000, value="LC/ie" idsrc="xmltag.org">Ireland. (Elsevier - www.elsevier.com; Neuroscience Letters - www.journals.elsevier.com/neuroscience-letters/)

The news correspondents report that additional information may be obtained from T. Yokota, value="ACORN:3297817221" idsrc="xmltag.org">Tokyo Medical & Dental University, Center Brain Integrat Res, Bunkyo Ku, value="LU/jp..tokyo" idsrc="xmltag.org">Tokyo 1138519, value="LC/jp" idsrc="xmltag.org">Japan. Additional authors for this research include T. Ohkubo, H. Kawaji, A. Machida, H. Miyata, S. Goda, S. Roy, Y. Hayashizaki, H. Suzuki and T. Yokota (see also href="http://www.newsrx.com/search/topics/Nervous+System+Research+-+Neuroscience">Nervous value="Tokyo:3771" idsrc="xmltag.org">System Research - Neuroscience).

Keywords for this news article include: value="LU/jp..tokyo" idsrc="xmltag.org">Tokyo, Japan, value="LR/asp" idsrc="xmltag.org">Asia, Neuroscience, Nervous System Research, Genetics, value="ACORN:3297817221" idsrc="xmltag.org">Tokyo Medical and Dental University.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx LLC

(c) 2017 NewsRx LLC, source Health Newsletters

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