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Studies from M. Nishiwaki et al Further Understanding of Hemophagocytic Lymphohistiocytosis (Kikuchi-Fujimoto Disease Complicated with Reactive...

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12/08/2016 | 07:11pm CET

Studies from M. Nishiwaki et al Further Understanding of Hemophagocytic Lymphohistiocytosis (Kikuchi-Fujimoto Disease Complicated with Reactive Hemophagocytic Lymphohistiocytosis)

By a News Reporter-Staff News Editor at Hematology Week -- Fresh data on Lymphatic Diseases and Conditions - Hemophagocytic Lymphohistiocytosis are presented in a new report. According to news originating from value="LU/jp..kyoto" idsrc="xmltag.org">Kyoto, Japan, by NewsRx correspondents, research stated, "Kikuchi-Fujimoto disease (KFD) is a benign cause of self-limiting subacute necrotizing lymphadenitis. KFD is rarely complicated with reactive hemophagocytic lymphohistiocytosis (HLH), and the clinical features of the simultaneous occurrence of these conditions are uncertain."

Our news journalists obtained a quote from the research, "A 30-year-old Japanese man with a persistent fever and sore throat presented to our hospital for treatment. Laboratory analysis showed bicytopenia, and radiological studies showed systemic lymphadenopathy accompanied by splenomegaly. A bone marrow examination showed hemophagocytic macrophages, suggesting HLH. Malignant lymphoma was suspected as a possible underlying disease, but the histology of the lymph nodes led to a final diagnosis of KFD and treatment with prednisolone (1 mg/kg/day), resulting in clinical improvement. This case highlighted the importance and difficulty of differentiating KFD from malignant lymphoma as an underlying condition of HLH. The literature review showed that patients with HLH-associated KFD may have higher serum ferritin and lactate dehydrogenase levels compared to typical KFD cases. Definite diagnosis based on pathological examination is essential for a better understanding of this rare disease. The presence of systemic lymphadenopathy does not exclude the possibility of KFD."

According to the news editors, the research concluded: "This case serves to remind physicians that KFD is a potential etiology of HLH."

For more information on this research see: Kikuchi-Fujimoto Disease Complicated with Reactive Hemophagocytic Lymphohistiocytosis. style="i">Acta Medica Okayama, 2016;70(5):383-388. style="i">Acta Medica Okayama can be contacted at: Okayama Univ Med School, Editorial Office, Acta Medica Okayama Okayama University Medical School 2-5-1 Shikata-Cho, Kita-Ku, Okayama, 700-8558, value="LC/jp" idsrc="xmltag.org">Japan (see also Lymphatic Diseases and Conditions - Hemophagocytic Lymphohistiocytosis).

The news correspondents report that additional information may be obtained from M. Nishiwaki, Rakuwakai Otowa Hosp, Dept. of Gen Internal Med, value="LU/jp..kyoto" idsrc="xmltag.org">Kyoto 6078062, value="LC/jp" idsrc="xmltag.org">Japan. Additional authors for this research include H. Hagiya and T. Kamiya.

Keywords for this news article include: value="LU/jp..kyoto" idsrc="xmltag.org">Kyoto, Japan, value="LR/asp" idsrc="xmltag.org">Asia, Hemophagocytic Lymphohistiocytosis, Lymphatic Diseases and Conditions, value="Tokyo:5970" idsrc="xmltag.org">Kikuchi-fujimoto Disease, Fujimoto Disease.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2016, NewsRx LLC

(c) 2016 NewsRx LLC, source Health Newsletters

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