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Boston Scientific Corporation : Patent Application Titled "Systems and Methods to Reduce Syncope Risk during Neural Stimulation Therapy" Published Online

01/02/2014 | 08:03pm US/Eastern
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By a News Reporter-Staff News Editor at Politics & Government Week -- According to news reporting originating from Washington, D.C., by VerticalNews journalists, a patent application by the inventors Mokelke, Eric A. (White Bear Lake, MN); Shome, Shibaji (Arden Hills, MN); Alvarez, Guy (Lino Lakes, MN); Bos, Harlan (Stillwater, MN); Stein, Kenneth Martin (Minneapolis, MN); Hatlestad, John D. (Maplewood, MN), filed on May 14, 2013, was made available online on December 26, 2013.

The assignee for this patent application is Cardiac Pacemakers, Inc.

Reporters obtained the following quote from the background information supplied by the inventors: "Therapies that are based on autonomic modulation have shown efficacy in a variety of diseases, including cardiovascular diseases, in both preclinical and clinical studies. The autonomic balance can be modulated to have more parasympathetic tone by stimulating nerve traffic in parasympathetic targets or inhibiting nerve traffic in sympathetic targets, and can be modulated to have more sympathetic tone by stimulating nerve traffic in sympathetic targets or inhibiting nerve traffic in parasympathetic targets.

"Sympathetic overactivation is involved in a variety of cardiovascular disease, such as ventricular arrhythmias, myocardial infarction (MI), heart failure (HF), etc. For example, vagus nerve stimulation, which generally increases parasympathetic tone, has been proposed as a therapy for cardiovascular problems such as cardiac rhythm management, myocardial infarction and ischemia, heart failure (HF), hypertension, and sleep disordered breathing. Further, by way of example, vagal stimulation also has been proposed as a therapy for epilepsy, depression, pain, migraines, eating disorders/obesity, and movement disorders. Stimulation of other neural targets has been proposed. For example, stimulation of baroreceptor regions or the carotid sinus nerve has been proposed to treat hypertension, deep brain stimulation has been proposed to treat depression and dementia, and spinal cord stimulation has been proposed to treat pain."

In addition to obtaining background information on this patent application, VerticalNews editors also obtained the inventors' summary information for this patent application: "Some embodiments, by way of example, provide a system, comprising a posture change detector configured to detect a posture transition indicative of an increased risk of syncope, and a neural stimulator configured to deliver a neural stimulation therapy. The neural stimulator may include a syncope avoidance module configured to respond to a detected posture transition by temporarily overriding the neural stimulation therapy to ameliorate the risk of increased syncope.

"Some embodiments, by way of example, provide a method, comprising delivering a neural stimulation therapy, detecting a posture transition indicative of an increased risk of syncope, and temporarily overriding the neural stimulation therapy in response to detecting the posture transition to ameliorate the risk of increased syncope.

"Some embodiments, by way of example, provide a posture monitor configured to monitor posture of a patient, comprising an activity sensor an activity sensor configured to sense patient activity and a posture sensor configured to sense patient posture. The posture monitor may include an activity sampler configured to control the activity sensor to sample patient activity and detect an increase in patient activity, and a posture sampler configured to control the posture sensor, in response to a detected increase in patient activity, to sample patient posture.

"Some embodiments, by way of example, provide a method for monitoring patient posture, comprising sampling patient activity using an activity sensor configured to sense patient activity and detect an increase in patient activity, and sampling patient posture in response to a detected increase in patient activity using a posture sensor configured to sense patient posture.

"This Summary is an overview of some of the teachings of the present application and not intended to be an exclusive or exhaustive treatment of the present subject matter. Further details about the present subject matter are found in the detailed description and appended claims. The scope of the present invention is defined by the appended claims and their equivalents.

BRIEF DESCRIPTION OF THE DRAWINGS

"Various embodiments are illustrated by way of example in the figures of the accompanying drawings. Such embodiments are demonstrative and not intended to be exhaustive or exclusive embodiments of the present subject matter.

"FIG. 1 illustrates a transition between posture states indicative of a risk of syncope, and the therapy override to ameliorate the risk of syncope according to an example of the present subject matter.

"FIG. 2 illustrates, by way of example and not limitation, and embodiment of a neural stimulation system with a syncope avoidance routine to reduce a risk of postural syncope.

"FIG. 3 illustrates, by way of example and not limitation, an embodiment of a syncope avoidance module that may be integrated with or part of the stimulation control circuit.

"FIG. 4 illustrates, by way of example and not limitation, an embodiment of a posture change detector.

"FIG. 5 illustrates, by way of example and not limitation, an embodiment of a posture monitor.

"FIG. 6 illustrates, by way of example and not limitation, an embodiment of a posture monitor that uses activity to control the sampling of the patient's posture.

"FIG. 7 illustrates an example of a posture analyzer 713 that considers both a threshold posture 718 and a rate of posture change 719.

"FIG. 8 illustrates an example of a posture analyzer 843 that considers a posture state 820, and changes 821 between posture states.

"FIG. 9 illustrates an example of a posture analyzer 913 that monitors posture 922, a posture change 923 and a direction 924 of a posture change.

"FIG. 10 illustrates an example of a posture monitor 1014 that uses blended sensor 1030 to determine a posture state 1031 and posture changes between states.

"FIG. 11 illustrates, by way of example and not limitation, an embodiment for controlling neural stimulation to reduce a risk of postural syncope.

"FIG. 12 illustrates an example of a process that may be performed by an embodiment of a barostimulation system.

"FIG. 13 illustrates an example of a process that may be performed by an embodiment of a barostimulation system that includes blended sensor information.

"FIG. 14 illustrates, by way of example and not limitation, an embodiment of a neural stimulation circuit with a syncope avoidance routine to reduce a risk of posture-induced syncope.

"FIG. 15 illustrates, by way of example, an embodiment of a therapy titration module 1563 such as is illustrated at 1463 in FIG. 14.

"FIG. 16 illustrates, by way of example not limitation, an embodiment of a controller for a neural stimulation device.

"FIG. 17 illustrates intermittent stimulation with variable stimulation periods (SP) and duty cycles (DC).

"FIG. 18 illustrates intermittent stimulation with constant stimulation periods (SP) and duty cycles (DC)."

For more information, see this patent application: Mokelke, Eric A.; Shome, Shibaji; Alvarez, Guy; Bos, Harlan; Stein, Kenneth Martin; Hatlestad, John D. Systems and Methods to Reduce Syncope Risk during Neural Stimulation Therapy. Filed May 14, 2013 and posted December 26, 2013. Patent URL: http://appft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&u=%2Fnetahtml%2FPTO%2Fsearch-adv.html&r=1412&p=29&f=G&l=50&d=PG01&S1=20131219.PD.&OS=PD/20131219&RS=PD/20131219

Keywords for this news article include: Therapy, Cardiac Pacemakers Inc..

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

© NewsRx.com, Acquiremedia 2014
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