New Molecular and Cellular Biology Study Results Reported from W.O. Miles et al (Post-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cells)
By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Life Science Research. According to news reporting originating from Milan, Italy, by NewsRx correspondents, research stated, "Inactivation of the retinoblastoma tumor suppressor (pRb) is a common oncogenic event that alters the expression of genes important for cell cycle progression, senescence, and apoptosis. However, in many contexts, the properties of pRb-deficient cells are similar to wild-type cells suggesting there may be processes that counterbalance the transcriptional changes associated with pRb inactivation."
Our news editors obtained a quote from the research, "Therefore, we have looked for sets of evolutionary conserved, functionally related genes that are direct targets of pRb/E2F proteins. We show that the expression of NANOS, a key facilitator of the Pumilio (PUM) post-transcriptional repressor complex, is directly repressed by pRb/E2F in flies and humans. In both species, NANOS expression increases following inactivation of pRb/RBF1 and becomes important for tissue homeostasis. By analyzing datasets from normal retinal tissue and pRb-null retinoblastomas, we find a strong enrichment for putative PUM substrates among genes de-regulated in tumors. These include pro-apoptotic genes that are transcriptionally down-regulated upon pRb loss, and we characterize two such candidates, MAP2K3 and MAP3K1, as direct PUM substrates."
According to the news editors, the research concluded: "Our data suggest that NANOS increases in importance in pRb-deficient cells and helps to maintain homeostasis by repressing the translation of transcripts containing PUM Regulatory Elements (PRE)."
For more information on this research see: Post-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cells. Embo Journal, 2014;33(19):2201-2215. Embo Journal can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA (see also Life Science Research).
The news editors report that additional information may be obtained by contacting W.O. Miles, Ist Sci San Raffaele, Center Translat Genom & Bioinformat, I-20132 Milan, Italy. Additional authors for this research include M. Korenjak, L.M. Griffiths, M.A. Dyer, P. Provero and N.J. Dyson.
Keywords for this news article include: Milan, Italy, Europe, Life Science Research
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC