REGULATED INFORMATION

PUBLICATION IN ACCORDANCE WITH ARTICLE 14 OF THE BELGIAN LAW

OF 2 MAY 2007 REGARDING THE PUBLICATION OF MAJOR SHAREHOLDINGS

(THE "TRANSPARENCY LAW")

GHENT, Belgium, 12 February 2018 - Ablynx [Euronext Brussels and Nasdaq: ABLX] today announced, in accordance with Article 14 of the Belgian Law of 2 May 2007 regarding the publication of major shareholdings in issuers whose securities are admitted to trading on a regulated market (the "Transparency Law"), that it received two notifications of shareholdings from FMR LLC on 7 and 8 February 2018.

FMR LLC (taking into account the holdings of its subsidiary undertakings) now holds a total of 4,444,329 voting securities of Ablynx, representing 5.92% of the current 75,065,990 outstanding voting rights of Ablynx (versus 7.84% notified previously on 6 February 2018).

FMR LLC has notified Ablynx that FMR Co., Inc., a subsidiary of Fidelity Management & Research Company, which itself is a subsidiary of FMR LLC (the ultimate parent company) has downward crossed the 5% threshold of total voting rights since 6 February 2018 and downward crossed the 3% threshold of voting rights held through financial instruments since 7 February 2018.

The latest notification contains the following information:

  • - Reason for the notification:

    • o acquisition or disposal of financial instruments that are treated as voting securities

  • - Notification by: a parent undertaking or a controlling person

  • - Persons subject to the notification requirement: FMR LLC

  • - Transaction date: 7 February 2018

  • - Threshold that is crossed: 3% of voting rights held through financial instruments

  • - Denominator: 75,065,990

  • - Details of the notification:

Name of select subsidiaries of FMR LLC

% of voting rights

% of voting rights held through financial instruments*

Total of both

FMR LLC

Fidelity Management & Research Company FMR Co., Inc.

1.28%

2.76%

4.04%

FMR LLC

FIAM Holdings Corp.

Fidelity Institutional Asset Management Trust Company

1.03%

1.03%

FMR LLC

FIAM Holdings Corp. FIAM LLC

0.85%

0.85%

TOTAL

3.16%

2.76%

5.92%

* Type of financial instrument: "Right of Recall"

-Chain of controlled undertakings through which the holding is effectively being held: The holdings attributable to FMR LLC arise from holdings of various undertakings for collective investment that are managed by FMR Co., Inc., Fidelity Institutional Asset Management Trust Company and FIAM LLC, each of which are entities that are subsidiaries of, and controlled by, FMR LLC. These undertakingsfor collective investment have granted FMR LLC discretionary power to vote the securities in accordance with the FMR LLC board proxy voting policy. FMR LLC is not a controlled undertaking.

More information is available in the transparency notification. A full version of the transparency notification is available on Ablynx website, under the sectionInvestors.

The articles of the association of Ablynx NV provide for shareholders notification threshold of 3%, 5% or a multiple of 5% of the total number of existing voting rights.

About Ablynx

Ablynx is a biopharmaceutical company engaged in the development ofNanobodies®, proprietary therapeutic proteins based on single-domain antibody fragments, which combine the advantages of conventional antibody drugs with some of the features of small-molecule drugs. Ablynx is dedicated to creating new medicines which will make a real difference to society. Today, the Company has more than45proprietary and partnered programmes in development in various therapeutic areas including inflammation, haematology, immuno-oncology, oncology and respiratory disease. The Company has collaborations with multiple pharmaceutical companies including AbbVie; Boehringer Ingelheim; Eddingpharm; Merck & Co., Inc., Kenilworth, New Jersey, USA; Merck KGaA; Novartis; Novo Nordisk; Sanofi and Taisho Pharmaceuticals. The Company is headquartered in Ghent, Belgium. More information can be found onwww.ablynx.com.

For more information, please contact:

Ablynx

Dr Edwin Moses CEO t: +32 (0)9 262 00 07 m: +32 (0)473 39 50 68 e:edwin.moses@ablynx.comLies Vanneste Director IR t: +32 (0)9 262 0137 m: +32 (0)498 05 35 79 e:lies.vanneste@ablynx.com

@AblynxABLX

Ablynx media relations:

Consilium Strategic Communications Mary-Jane Elliott, Philippa Gardner, Sukaina Virji t: +44 (0)20 3709 5700 e:ablynx@consilium-comms.com

Joele Frank, Wilkinson Brimmer Katcher Dan Katcher or Joseph Sala t: +1 212-355-4449

Ablynx NV published this content on 12 February 2018 and is solely responsible for the information contained herein.
Distributed by Public, unedited and unaltered, on 12 February 2018 06:20:03 UTC.

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