GI Dynamics, Inc. - ASX Announcement

Data Presented at ADA Show the Effects of GI Dynamics' EndoBarrier® Therapy on Glycemic Control and Reducing Diabetes Medication in Patients with Type 2 Diabetes and Obesity

Data Presented at the Scientific Sessions of the American Diabetes Association Demonstrate Increased Bile Acids Levels Following EndoBarrier Therapy; Further Establishes Potential Mechanism of Action

SAN FRANCISCO, United States and SYDNEY, Australia - 16 June 2014 - GDI ynamicsI,nc. (ASX: GID)ma, edicadlevicceompandevelopininnovati vtereatmentfsotrypd2eiabeteasnd

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gnlycemicontroli,tasbility troeducreeliancoedniabetems edications,
includininsulina,ws elalfsi ndingtshahtelexpl aiintpsotentiaml ech anismoafctionT. hese findingws erperesentedinthr epeosteprresentationastth7e4 tSh cientifiScessionostfhAe merican DiabeteAs ssociatioiSnaFrancisco.
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medicaml eetingasndfurthevralidatheowthEe
ndoBarriedrevicwe orktsoaffecatndimprove
glycemicontrol,s"aiDaviMaggsM, .Dc.,hief medicaolfficerG,DI ynamicsI,nc".Thfeindings fromthessetudieasnanalysesshowthaEt ndo BarrieprositivelimpactHs bA1acnweighitn patientws ittypd2eiabeteasnobesityI.mporta ntlyt,hfeindingaslso showthaEt ndoBarrier Therapcareducreeliancoedniabetes medicationsf,romoraalgents tionsulitnherapyT. hiisasn importanctonsiderationfoprhysicianastsheyco ntemplattereatmenrtegimenfsotrheipratients."

Acute Effects on Glucose; Impact on Satiety and Insulin Requirements Findingfsromthsetudy",ThAe cutEe ffecotf EndoBarrieTr reatmenotn GlucosHe omeostasiisn ObesUe ncontrolleDiabetiScubjects,e"valuate dtheffectostfhEe ndoBarriedrevicoenglucose homeostasisH, bA1cw, eighltossi,nsulirequire mentasndappetitien33patientsG. lucoswe as monitorecdontinuouslfyoorne weebkeginnintgwdoaybsefore placemenottfhdeevice.

UsoetfhEe ndoBarriedrevicreesulteianancute droianveragdeailglucosbe2y9%withidays positmplantationd,espitraeeduction o5f0%iinsulidosdeurinth itsimeA. esarlya1s2weeks afteEr ndoBarrieirnsertions,ubjec tdsemonstratesadignificanrteduc tioinbnotwh eigh(t-8.k9ga)nd HbA1lcevel(s-1.4%l)eadingtoa decreasieinnsulin requirementsI.nterestinglyw, eighltosws as accompaniedbdyaecreasienappetitdeem onstratebdtyhveisuaalnalosgcale.
"ThaebilitotfhEe ndoBarrietraocutelaffect glucosheomeostasisb,efore significanwt eighltoss hahsacdahancteoccuirfsascin atingandresemblerseportosnbari atriscurgery,s"tatedGabriella LiebermanM, .D.I,nstitutoeEf ndocrinologyS,hebMa edi caCl enterT, eAl vivI,s rael".Thfeactthat thdeeviciempactaslwl eightg,lucosaendappetite makeiastttractivfeotrhtereatmenotdfiabesity
www.gidynamics.com

US OFFICE & HEADQUARTERS: 25 Hartwell Avenue, Lexington MA 02421 T +1 (781) 357-3300 F +1 (781) 357-3301

EUROPEAN OFFICE: De Tweeling 20-22 's-Hertogenbosch 5215 MC, THE NETHERLANDS T: + 31 13 547 9300

AUSTRALIAN OFFICE: Level 8, 17-19 Bridge Street, Sydney, NSW 2000 T +61 2 9325 9046

GI Dynamics, Inc., is a corporation incorporated in Delaware, USA, whose stockholders have limited liability. ARBN 151 239 388

GI Dynamics, Inc. - ASX Announcement Page 2

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Improvements in HbA1c, Weight Loss and Reduction of Oral Diabetes Medications

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teheffectosf thEe ndoBarrier
devictelooweHr bA1ca,cceleratwe eighltosas
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ThuesoetfhEe ndoBarriedrevi creesulteid1an.4%mediadn
ecreasieHn bA1(cfrom8.2%at
baselinte6o.8)o;tfhes5e7%achievethre
AssociationP.atientesxperienced
ecommended7%HbA1octfhAe mericanDiabetes raobusetffecottnotablodweight losws ithEndoBarrieTr herapy,
resultinig1an0.4%reductio(nf rom106.abtaselinte9o3.kg)N. otablyp,atientws eraeblteo reducuesoebfackgroundiabetems edications.

Increased Levels of Bile Acids Following Treatment with EndoBarrier Researchaisndicatetdhabtile acidlsevelms aybe tiettoheffectiv enesosgfastribcypass surgerys,ucaRs oux-en-Ygastribcypas(sRYGB )T. hperesentation",Duodenal-JejunaBl ypass LineIrncreaseBs ilAe cidLs evelisPnatientws ith SeverOe besitanTypD2e iabeteMs ellitus" investigatetdhuesoef thEe ndoBarriedrevicaend itesffectosbnilaecids toexplorietpsotential mechanismoafction.

Primaransecondarbilaecidlsevelws erme easur eidsnevepnatientws
itthypd2eiabeteasnd
obesitypriotroplacemenottfhEe ndoBarriedrevi caendfollowingremovaal5t2weekostfreatment. Aftetrreatmentf,asti ntgotablilaecidlseve lisncreasetd4o.3±0.8 μmol/L(from0.7±0.3 μmol/L baselinep;<0.05)A. lsof,asting primary(from0.04±0.01to2.1±0.4 μmol/La)ndsecondary(from
0.07±0.0t1o.5±0.4 μmol/Lb)ilaecidlsevelisn creasefrombaselin(ep<0.0vsb.aselinfeobroth). Thesfeindingosffefrurtheirnsighitntthme ech anismtshautnderlitehe therapeutiecffecotf EndoBarrieTr herapy.
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ThEe ndoBarriedreviciecsurrentlyundeirnvestigati oninthUe .Sim.na ulti centerp,ivotacllinical trial (ThEe NDOTrial) fotrhtereatmenotpfatientws hohave uncontrolletypd2eiabeteasnare obeseE. ndoBarrieTr herapyhabseenapprovedinse lecctountrieisnterna tionallsyinc2e01a0nids availablieCn hileA, ustralia ansdelecctountrieisEn ur opaentdhMe iddlEe ast.

www.gidynamics.com

US OFFICE & HEADQUARTERS: 25 Hartwell Avenue, Lexington MA 02421 T +1 (781) 357-3300 F +1 (781) 357-3301

EUROPEAN OFFICE: De Tweeling 20-22 's-Hertogenbosch 5215 MC, THE NETHERLANDS T: + 31 13 547 9300

AUSTRALIAN OFFICE: Level 8, 17-19 Bridge Street, Sydney, NSW 2000 T +61 2 9325 9046

GI Dynamics, Inc., is a corporation incorporated in Delaware, USA, whose stockholders have limited liability. ARBN 151 239 388

GI Dynamics, Inc. - ASX Announcement Page 3

About GI Dynamics

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treatmenotfyp2deiabeteasnd/oorbesityE. ndoBarrieiars

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hUe .S.

EndoBarrieinrsoatpprovedfosralietnh

Ue .Sa.ndilsimitebdyfederallawto investigationaulsoenlyinthUe nitedStates

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Dynamiciscsonductinpagivotal clinicatlriaolEf ndoBarrier itnhUe .Sf.otrhtereatmenotpfati entws hohavuencontrolletdyp2e diabeteasnadroebeseF.oundedin2003G, I DynamicishseadquartereidLn exingtonM, a ssachusettsF.omr orienformationp,lease visit www.gidynamics.com.

Forward-Looking Statements

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Investor Enquiries: Media Enquiries:

UnitedStates

RoberCt raneC, hieFfinanciaOl fficer

+(17813)57-3250

UnitedStates/Europe: DaBn udwickP,urCe ommunicationIsnc.

+(19732)71-6085

Australia

DaviAd lleonJrohGn rangerH, awkesburPyartners

PtLimited

+69213295046

Australia

AngelCa eberanoF,lourisPhR

+69310982445

www.gidynamics.com

US OFFICE & HEADQUARTERS: 25 Hartwell Avenue, Lexington MA 02421 T +1 (781) 357-3300 F +1 (781) 357-3301

EUROPEAN OFFICE: De Tweeling 20-22 's-Hertogenbosch 5215 MC, THE NETHERLANDS T: + 31 13 547 9300

AUSTRALIAN OFFICE: Level 8, 17-19 Bridge Street, Sydney, NSW 2000 T +61 2 9325 9046

GI Dynamics, Inc., is a corporation incorporated in Delaware, USA, whose stockholders have limited liability. ARBN 151 239 388

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