AMENDMENT Section (2a)

FORM 8.5 (EPT/RI)

PUBLIC DEALING DISCLOSURE BY AN EXEMPT PRINCIPAL TRADER WITH RECOGNISED INTERMEDIARY STATUS DEALING IN A CLIENT-SERVING CAPACITY

Rule 8.5 of the Takeover Code (the 'Code')

1. KEY INFORMATION

(a) Name of exempt principal trader:

Morgan Stanley & Co. International plc

(b) Name of offeror/offeree in relation to whose relevant securities this form relates:

Use a separate form for each offeror/offeree

Shire plc

(c) Name of the party to the offer with which exempt principal trader is connected:

Shire plc

(d) Date dealing undertaken:

18 JULY 2018

(e)Has the EPT previously disclosed, or is it today disclosing, under the Code in respect of any other party to this offer?

Yes - Takeda Pharmaceutical Company Limited

2. DEALINGS BY THE EXEMPT PRINCIPAL TRADER

Where there have been dealings in more than one class of relevant securities of the offeror or offeree named in 1(b), copy table 2(a), (b), (c) or (d) (as appropriate) for each additional class of relevant security dealt in.

The currency of all prices and other monetary amounts should be stated.

(a) Purchases and sales

Class of relevant security

Purchases/sales

Total number of securities

Highest price per unit paid/received

Lowest price per unit paid/received

5p ordinary

PURCHASES

313,638

44.0950 GBP

43.6700 GBP

5p ordinary

SALES

560,271

44.0800 GBP

43.5800 GBP

5p ordinary

PURCHASES

197,500

57.4715 USD

57.3622 USD

5p ordinary

SALES

21,517

57.5092 USD

57.5092 USD

(b) Cash-settled derivative transactions

Class of relevant security

Product description

e.g. CFD

Nature of dealing

e.g. opening/closing a long/short position, increasing/reducing a long/short position

Number of reference securities

Price per unit

ADR

CFD

LONG

26

172.6100 USD

ADR

CFD

LONG

113

172.7400 USD

ADR

CFD

LONG

112

172.7400 USD

ADR

CFD

LONG

31

172.7400 USD

ADR

CFD

LONG

157

172.7400 USD

ADR

CFD

LONG

114

172.7400 USD

ADR

CFD

LONG

114

172.7400 USD

ADR

CFD

SHORT

89

172.3900 USD

ADR

CFD

SHORT

90

172.3900 USD

ADR

CFD

SHORT

113

172.3900 USD

ADR

CFD

SHORT

112

172.3900 USD

ADR

CFD

SHORT

112

172.3900 USD

ADR

CFD

SHORT

113

172.3900 USD

ADR

CFD

SHORT

9

172.7400 USD

ADR

CFD

SHORT

10

172.7400 USD

5p ordinary

CFD

LONG

3,391

43.9402 GBP

5p ordinary

CFD

LONG

6,000

43.9402 GBP

5p ordinary

CFD

LONG

14,000

43.9402 GBP

5p ordinary

CFD

LONG

11,555

43.9516 GBP

5p ordinary

CFD

LONG

12

43.9550 GBP

5p ordinary

CFD

LONG

71

43.9550 GBP

5p ordinary

CFD

LONG

6,807

43.9855 GBP

5p ordinary

CFD

LONG

49,320

43.9901 GBP

5p ordinary

CFD

LONG

40,149

43.9901 GBP

5p ordinary

CFD

LONG

721

44.0025 GBP

5p ordinary

CFD

LONG

420

44.0071 GBP

5p ordinary

CFD

SHORT

11,726

43.9068 GBP

5p ordinary

CFD

SHORT

6,807

43.9486 GBP

5p ordinary

CFD

SHORT

13

43.9592 GBP

5p ordinary

CFD

SHORT

1,800

43.9721 GBP

5p ordinary

CFD

SHORT

346

43.9782 GBP

5p ordinary

CFD

SHORT

29

43.9858 GBP

5p ordinary

CFD

SHORT

29

43.9858 GBP

5p ordinary

CFD

SHORT

96

43.9858 GBP

5p ordinary

CFD

SHORT

2,000

44.0098 GBP

5p ordinary

CFD

SHORT

3

44.0400 GBP

5p ordinary

CFD

SHORT

196

43.9933 GBP

5p ordinary

CFD

SHORT

1,301

43.9933 GBP

5p ordinary

CFD

SHORT

264

43.9933 GBP

5p ordinary

CFD

SHORT

342

43.9933 GBP

5p ordinary

CFD

SHORT

525

57.4715 USD

5p ordinary

CFD

SHORT

26,970

57.4715 USD

5p ordinary

CFD

SHORT

25,000

57.4807 USD

5p ordinary

CFD

SHORT

25,000

57.4843 USD

(c) Stock-settled derivative transactions (including options)

(i) Writing, selling, purchasing or varying

Class of relevant security

Product description e.g. call option

Writing, purchasing, selling, varying etc.

Number of securities to which option relates

Exercise price per unit

Typee.g. American, European etc.

Expiry date

Option money paid/ received per unit

N/A

N/A

N/A

N/A

N/A

N/A

N/A

N/A

(ii) Exercise

Class of relevant security

Product descriptione.g. call option

Number of securities

Exercise price per unit

N/A

N/A

N/A

N/A

(d) Other dealings (including subscribing for new securities)

Class of relevant security

Nature of dealinge.g. subscription, conversion

Details

Price per unit (if applicable)

N/A

N/A

N/A

N/A

The currency of all prices and other monetary amounts should be stated.

Where there have been dealings in more than one class of relevant securities of the offeror or offeree named in 1(b), copy table 2(a), (b), (c) or (d) (as appropriate) for each additional class of relevant security dealt in.

3. OTHER INFORMATION

(a) Indemnity and other dealing arrangements

Details of any indemnity or option arrangement, or any agreement or understanding, formal or informal, relating to relevant securities which may be an inducement to deal or refrain from dealing entered into by the exempt principal trader making the disclosure and any party to the offer or any person acting in concert with a party to the offer:

If there are no such agreements, arrangements or understandings, state 'none'

None

(b) Agreements, arrangements or understandings relating to options or derivatives

Details of any agreement, arrangement or understanding, formal or informal, between the exempt principal trader making the disclosure and any other person relating to:

(i) the voting rights of any relevant securities under any option; or

(ii) the voting rights or future acquisition or disposal of any relevant securities to which any derivative is referenced:

If there are no such agreements, arrangements or understandings, state 'none'

None

Date of disclosure:

20 JULY 2018

Contact name:

Craig Horsley

Telephone number:

+44(141) 245 7736

Public disclosures under Rule 8 of the Code must be made to a Regulatory Information Service and must also be emailed to the Takeover Panel atmonitoring@disclosure.org.uk. The Panel's Market Surveillance Unit is available for consultation in relation to the Code's dealing disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel's website atwww.thetakeoverpanel.org.uk.

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Shire plc published this content on 20 July 2018 and is solely responsible for the information contained herein. Distributed by Public, unedited and unaltered, on 20 July 2018 12:52:03 UTC