AMENDMENT Section (2a)

FORM 8.5 (EPT/RI)

PUBLIC DEALING DISCLOSURE BY AN EXEMPT PRINCIPAL TRADER WITH RECOGNISED INTERMEDIARY STATUS DEALING IN A CLIENT-SERVING CAPACITY

Rule 8.5 of the Takeover Code (the 'Code')

1. KEY INFORMATION

(a) Name of exempt principal trader:

Morgan Stanley & Co. International plc

(b) Name of offeror/offeree in relation to whose relevant securities this form relates:

Use a separate form for each offeror/offeree

Shire plc

(c) Name of the party to the offer with which exempt principal trader is connected:

Shire plc

(d) Date dealing undertaken:

12 JULY 2018

(e)Has the EPT previously disclosed, or is it today disclosing, under the Code in respect of any other party to this offer?

Yes - Takeda Pharmaceutical Company Limited

2. DEALINGS BY THE EXEMPT PRINCIPAL TRADER

Where there have been dealings in more than one class of relevant securities of the offeror or offeree named in 1(b), copy table 2(a), (b), (c) or (d) (as appropriate) for each additional class of relevant security dealt in.

The currency of all prices and other monetary amounts should be stated.

(a) Purchases and sales

Class of relevant security

Purchases/sales

Total number of securities

Highest price per unit paid/received

Lowest price per unit paid/received

ADR

PURCHASES

5,100

171.7800 USD

170.6000 USD

ADR

SALES

5,100

171.7800 USD

170.6000 USD

5p ordinary

PURCHASES

470,422

43.4350 GBP

42.9200 GBP

5p ordinary

SALES

489,923

43.4600 GBP

42.9250 GBP

5p ordinary

PURCHASES

51,134

57.3509 USD

57.1755 USD

(b) Cash-settled derivative transactions

Class of relevant security

Product description

e.g. CFD

Nature of dealing

e.g. opening/closing a long/short position, increasing/reducing a long/short position

Number of reference securities

Price per unit

ADR

CFD

LONG

102

172.2900 USD

ADR

CFD

LONG

103

172.2900 USD

ADR

CFD

LONG

13

172.2900 USD

ADR

CFD

LONG

269

172.2900 USD

ADR

CFD

LONG

13

172.2900 USD

ADR

CFD

LONG

270

172.2900 USD

ADR

CFD

SHORT

270

171.9700 USD

ADR

CFD

SHORT

269

171.9700 USD

ADR

CFD

SHORT

233

171.9700 USD

ADR

CFD

SHORT

234

171.9700 USD

ADR

CFD

SHORT

565

172.2900 USD

ADR

CFD

SHORT

564

172.2900 USD

5p ordinary

CFD

LONG

4,528

43.0385 GBP

5p ordinary

CFD

LONG

815

43.0385 GBP

5p ordinary

CFD

LONG

519

43.1913 GBP

5p ordinary

CFD

LONG

3,676

43.3093 GBP

5p ordinary

CFD

LONG

7,764

43.3339 GBP

5p ordinary

CFD

LONG

145

43.4021 GBP

5p ordinary

CFD

SHORT

566

43.0183 GBP

5p ordinary

CFD

SHORT

142

43.0428 GBP

5p ordinary

CFD

SHORT

519

43.0791 GBP

5p ordinary

CFD

SHORT

88

43.1156 GBP

5p ordinary

CFD

SHORT

5,343

43.1757 GBP

5p ordinary

CFD

SHORT

2,861

43.2866 GBP

5p ordinary

CFD

SHORT

9

43.3600 GBP

5p ordinary

CFD

SHORT

2,202

43.3600 GBP

5p ordinary

CFD

SHORT

2,202

43.3600 GBP

5p ordinary

CFD

SHORT

5,000

42.9604 GBP

5p ordinary

CFD

SHORT

1,600

57.1755 USD

5p ordinary

CFD

SHORT

600

57.1755 USD

5p ordinary

CFD

SHORT

584

57.1755 USD

5p ordinary

CFD

SHORT

550

57.1755 USD

5p ordinary

CFD

SHORT

300

57.1755 USD

(c) Stock-settled derivative transactions (including options)

(i) Writing, selling, purchasing or varying

Class of relevant security

Product description e.g. call option

Writing, purchasing, selling, varying etc.

Number of securities to which option relates

Exercise price per unit

Typee.g. American, European etc.

Expiry date

Option money paid/ received per unit

N/A

N/A

N/A

N/A

N/A

N/A

N/A

N/A

(ii) Exercise

Class of relevant security

Product descriptione.g. call option

Number of securities

Exercise price per unit

N/A

N/A

N/A

N/A

(d) Other dealings (including subscribing for new securities)

Class of relevant security

Nature of dealinge.g. subscription, conversion

Details

Price per unit (if applicable)

N/A

N/A

N/A

N/A

The currency of all prices and other monetary amounts should be stated.

Where there have been dealings in more than one class of relevant securities of the offeror or offeree named in 1(b), copy table 2(a), (b), (c) or (d) (as appropriate) for each additional class of relevant security dealt in.

3. OTHER INFORMATION

(a) Indemnity and other dealing arrangements

Details of any indemnity or option arrangement, or any agreement or understanding, formal or informal, relating to relevant securities which may be an inducement to deal or refrain from dealing entered into by the exempt principal trader making the disclosure and any party to the offer or any person acting in concert with a party to the offer:

If there are no such agreements, arrangements or understandings, state 'none'

None

(b) Agreements, arrangements or understandings relating to options or derivatives

Details of any agreement, arrangement or understanding, formal or informal, between the exempt principal trader making the disclosure and any other person relating to:

(i) the voting rights of any relevant securities under any option; or

(ii) the voting rights or future acquisition or disposal of any relevant securities to which any derivative is referenced:

If there are no such agreements, arrangements or understandings, state 'none'

None

Date of disclosure:

16 JULY 2018

Contact name:

Craig Horsley

Telephone number:

+44(141) 245 7736

Public disclosures under Rule 8 of the Code must be made to a Regulatory Information Service and must also be emailed to the Takeover Panel atmonitoring@disclosure.org.uk. The Panel's Market Surveillance Unit is available for consultation in relation to the Code's dealing disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel's website atwww.thetakeoverpanel.org.uk.

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Shire plc published this content on 16 July 2018 and is solely responsible for the information contained herein. Distributed by Public, unedited and unaltered, on 16 July 2018 10:50:01 UTC