AMENDMENT Section (2b)

FORM 8.5 (EPT/RI)

PUBLIC DEALING DISCLOSURE BY AN EXEMPT PRINCIPAL TRADER WITH RECOGNISED INTERMEDIARY STATUS DEALING IN A CLIENT-SERVING CAPACITY

Rule 8.5 of the Takeover Code (the 'Code')

1. KEY INFORMATION

(a) Name of exempt principal trader:

Morgan Stanley & Co. International plc

(b) Name of offeror/offeree in relation to whose relevant securities this form relates:

Use a separate form for each offeror/offeree

Shire plc

(c) Name of the party to the offer with which exempt principal trader is connected:

Shire plc

(d) Date dealing undertaken:

18 JUNE 2018

(e)Has the EPT previously disclosed, or is it today disclosing, under the Code in respect of any other party to this offer?

Yes - Takeda Pharmaceutical Company Limited

2. DEALINGS BY THE EXEMPT PRINCIPAL TRADER

Where there have been dealings in more than one class of relevant securities of the offeror or offeree named in 1(b), copy table 2(a), (b), (c) or (d) (as appropriate) for each additional class of relevant security dealt in.

The currency of all prices and other monetary amounts should be stated.

(a) Purchases and sales

Class of relevant security

Purchases/sales

Total number of securities

Highest price per unit paid/received

Lowest price per unit paid/received

ADR

PURCHASES

3,001

159.0200 USD

158.6853 USD

ADR

SALES

3,001

159.0200 USD

158.6853 USD

5p ordinary

PURCHASES

556,021

40.8770 GBP

39.7700 GBP

5p ordinary

SALES

817,566

40.3100 GBP

39.7800 GBP

5p ordinary

PURCHASES

106,134

52.9613 USD

52.7917 USD

(b) Cash-settled derivative transactions

Class of relevant security

Product description

e.g. CFD

Nature of dealing

e.g. opening/closing a long/short position, increasing/reducing a long/short position

Number of reference securities

Price per unit

ADR

CFD

LONG

143

158.9100 USD

ADR

CFD

LONG

148

158.9600 USD

ADR

CFD

LONG

202

160.0500 USD

ADR

CFD

LONG

201

160.0500 USD

ADR

CFD

SHORT

148

160.0500 USD

5p ordinary

CFD

LONG

152

39.9200 GBP

5p ordinary

CFD

LONG

42

39.9533 GBP

5p ordinary

CFD

LONG

24,696

39.9795 GBP

5p ordinary

CFD

LONG

2,180

39.9800 GBP

5p ordinary

CFD

LONG

20,406

39.9854 GBP

5p ordinary

CFD

LONG

1,438

39.9868 GBP

5p ordinary

CFD

LONG

1,438

39.9887 GBP

5p ordinary

CFD

LONG

193

39.9887 GBP

5p ordinary

CFD

LONG

77

39.9887 GBP

5p ordinary

CFD

LONG

1,202

39.9887 GBP

5p ordinary

CFD

LONG

265

39.9887 GBP

5p ordinary

CFD

LONG

1,489

39.9887 GBP

5p ordinary

CFD

LONG

291

39.9887 GBP

5p ordinary

CFD

LONG

2,085

40.0000 GBP

5p ordinary

CFD

LONG

10,467

40.0000 GBP

5p ordinary

CFD

LONG

123

40.0001 GBP

5p ordinary

CFD

LONG

3,607

40.0166 GBP

5p ordinary

CFD

LONG

1,000

40.2200 GBP

5p ordinary

CFD

SHORT

500

39.9000 GBP

5p ordinary

CFD

SHORT

33

39.9341 GBP

5p ordinary

CFD

SHORT

3,000

39.9580 GBP

5p ordinary

CFD

SHORT

4,500

39.9580 GBP

5p ordinary

CFD

SHORT

2,500

39.9619 GBP

5p ordinary

CFD

SHORT

23,334

39.9829 GBP

5p ordinary

CFD

SHORT

2,254

39.9829 GBP

5p ordinary

CFD

SHORT

22,660

39.9942 GBP

5p ordinary

CFD

SHORT

20

39.9950 GBP

5p ordinary

CFD

SHORT

3,472

40.0000 GBP

5p ordinary

CFD

SHORT

10,467

40.0000 GBP

5p ordinary

CFD

SHORT

500

40.0000 GBP

5p ordinary

CFD

SHORT

3,472

40.0000 GBP

5p ordinary

CFD

SHORT

298

40.0056 GBP

5p ordinary

CFD

SHORT

85

40.0056 GBP

5p ordinary

CFD

SHORT

4,770

40.5031 GBP

5p ordinary

CFD

SHORT

3,180

40.5031 GBP

5p ordinary

CFD

SHORT

2,820

40.8791 GBP

5p ordinary

CFD

SHORT

4,230

40.8791 GBP

5p ordinary

CFD

SHORT

5,000

39.8455 GBP

5p ordinary

CFD

SHORT

1,100

52.7917 USD

5p ordinary

CFD

SHORT

905

52.7917 USD

5p ordinary

CFD

SHORT

600

52.7917 USD

5p ordinary

CFD

SHORT

300

52.7917 USD

(c) Stock-settled derivative transactions (including options)

(i) Writing, selling, purchasing or varying

Class of relevant security

Product description e.g. call option

Writing, purchasing, selling, varying etc.

Number of securities to which option relates

Exercise price per unit

Typee.g. American, European etc.

Expiry date

Option money paid/ received per unit

N/A

N/A

N/A

N/A

N/A

N/A

N/A

N/A

(ii) Exercise

Class of relevant security

Product descriptione.g. call option

Number of securities

Exercise price per unit

N/A

N/A

N/A

N/A

(d) Other dealings (including subscribing for new securities)

Class of relevant security

Nature of dealinge.g. subscription, conversion

Details

Price per unit (if applicable)

N/A

N/A

N/A

N/A

The currency of all prices and other monetary amounts should be stated.

Where there have been dealings in more than one class of relevant securities of the offeror or offeree named in 1(b), copy table 2(a), (b), (c) or (d) (as appropriate) for each additional class of relevant security dealt in.

3. OTHER INFORMATION

(a) Indemnity and other dealing arrangements

Details of any indemnity or option arrangement, or any agreement or understanding, formal or informal, relating to relevant securities which may be an inducement to deal or refrain from dealing entered into by the exempt principal trader making the disclosure and any party to the offer or any person acting in concert with a party to the offer:

If there are no such agreements, arrangements or understandings, state 'none'

None

(b) Agreements, arrangements or understandings relating to options or derivatives

Details of any agreement, arrangement or understanding, formal or informal, between the exempt principal trader making the disclosure and any other person relating to:

(i) the voting rights of any relevant securities under any option; or

(ii) the voting rights or future acquisition or disposal of any relevant securities to which any derivative is referenced:

If there are no such agreements, arrangements or understandings, state 'none'

None

Date of disclosure:

22 JUNE 2018

Contact name:

Craig Horsley

Telephone number:

+44(141) 245 7736

Public disclosures under Rule 8 of the Code must be made to a Regulatory Information Service and must also be emailed to the Takeover Panel atmonitoring@disclosure.org.uk. The Panel's Market Surveillance Unit is available for consultation in relation to the Code's dealing disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel's website atwww.thetakeoverpanel.org.uk.

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Shire plc published this content on 22 June 2018 and is solely responsible for the information contained herein. Distributed by Public, unedited and unaltered, on 22 June 2018 07:37:08 UTC