Director/PDMR Shareholding

    January 16, 2017 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company")

    Notification of transactions by person discharging managerial responsibilities

    1.   Details of the person discharging managerial responsibilities       
         ("PDMR") / person closely associated with them ("PCA")              
                                                                             
    a)   Name              Jeff Poulton                                      
                                                                             
    2.   Reason for the notification                                         
                                                                             
    a)   Position / status Chief Financial Officer - PDMR                    
                                                                             
    b)   Initial           Initial notification                              
         notification /                                                      
         amendment                                                           
                                                                             
    3.   Details of the issuer, emission allowance participant, auction      
         platform, auctioneer or auction monitor                             
                                                                             
    a)   Name              Shire plc                                         
                                                                             
    b)   LEI               54930005LQRLI2UXRQ59                              
                                                                             
    4.   Details of the transaction(s): section to be repeated for (i) each  
         type of instrument; (ii) each type of transaction; (iii) each date; 
         and (iv) each place where transactions have been conducted          
                                                                             
    a)   Description of    Shire plc American Depositary Shares ("ADSs")     
         the financial                                                       
         instrument, type                                                    
         of instrument                                                       
                                                                             
         Identification    ISIN: US82481R1068                                
         code                                                                
                                                                             
    b)   Nature of the     Acquisition of ADSs following the automatic       
         transaction       re-investment of dividends received, as paid to   
                           shareholders on April 14, 2015. Mr. Poulton became
                           aware of the transaction on January 13, 2017.     
                                                                             
    c)   Price(s) and              Price(s)                 Volume(s)        
         volume(s)                                                           
                                  $246.6702                 3.904241         
                                                                             
    d)   Aggregated        N/A (single transaction)                          
         information                                                         
                                                                             
    e)   Date of the       April 14, 2015                                    
         transaction                                                         
                                                                             
    f)   Place of the      NASDAQ Global Select Market                       
         transaction                                                         
                                                                             
    5.   Details of the transaction(s): section to be repeated for (i) each  
         type of instrument; (ii) each type of transaction; (iii) each date; 
         and (iv) each place where transactions have been conducted          
                                                                             
    a)   Description of    Shire plc American Depositary Shares ("ADSs")     
         the financial                                                       
         instrument, type                                                    
         of instrument                                                       
                                                                             
         Identification    ISIN: US82481R1068                                
         code                                                                
                                                                             
    b)   Nature of the     Acquisition of ADSs following the automatic       
         transaction       re-investment of dividends received, as paid to   
                           shareholders on October 2, 2015. Mr. Poulton      
                           became aware of the transaction on January 13,    
                           2017.                                             
                                                                             
    c)   Price(s) and              Price(s)                 Volume(s)        
         volume(s)                                                           
                                   $205.13                  1.037245         
                                                                             
    d)   Aggregated        N/A (single transaction)                          
         information                                                         
                                                                             
    e)   Date of the       October 2, 2015                                   
         transaction                                                         
                                                                             
    f)   Place of the      NASDAQ Global Select Market                       
         transaction                                                         
                                                                             
    6.   Details of the transaction(s): section to be repeated for (i) each  
         type of instrument; (ii) each type of transaction; (iii) each date; 
         and (iv) each place where transactions have been conducted          
                                                                             
    a)   Description of    Shire plc American Depositary Shares ("ADSs")     
         the financial                                                       
         instrument, type                                                    
         of instrument                                                       
                                                                             
         Identification    ISIN: US82481R1068                                
         code                                                                
                                                                             
    b)   Nature of the     Acquisition of ADSs following the automatic       
         transaction       re-investment of dividends received, as paid to   
                           shareholders on April 12, 2016. Mr. Poulton became
                           aware of the transaction on January 13, 2017.     
                                                                             
    c)   Price(s) and              Price(s)                 Volume(s)        
         volume(s)                                                           
                                  $180.3824                 6.468702         
                                                                             
    d)   Aggregated        N/A (single transaction)                          
         information                                                         
                                                                             
    e)   Date of the       April 12, 2016                                    
         transaction                                                         
                                                                             
    f)   Place of the      NASDAQ Global Select Market                       
         transaction                                                         
                                                                             
    7.   Details of the transaction(s): section to be repeated for (i) each  
         type of instrument; (ii) each type of transaction; (iii) each date; 
         and (iv) each place where transactions have been conducted          
                                                                             
    a)   Description of    Shire plc American Depositary Shares ("ADSs")     
         the financial                                                       
         instrument, type                                                    
         of instrument                                                       
                                                                             
         Identification    ISIN: US82481R1068                                
         code                                                                
                                                                             
    b)   Nature of the     Acquisition of ADSs following the automatic       
         transaction       re-investment of dividends received, as paid to   
                           shareholders on October 7, 2016. Mr. Poulton      
                           became aware of the transaction on January 13,    
                           2017.                                             
                                                                             
    c)   Price(s) and              Price(s)                 Volume(s)        
         volume(s)                                                           
                                   $193.77                  1.262528         
                                                                             
    d)   Aggregated        N/A (single transaction)                          
         information                                                         
                                                                             
    e)   Date of the       October 7, 2016                                   
         transaction                                                         
                                                                             
    f)   Place of the      NASDAQ Global Select Market                       
         transaction                                                         

    Oliver Strawbridge
    Senior Assistant Company Secretary

    For further information please contact:

    Investor Relations                                                           
                                                                                 
    Ian Karp                        ikarp@shire.com            +1 781 482 9018   
                                                                                 
    Robert Coates                   rcoates@shire.com          +44 1256 894874   
                                                                                 
                                                                                 
    Media                                                                        
                                                                                 
    Lisa Adler                      lisa.adler@shire.com       +1 617 588 8607   
                                                                                 
    Debbi Ford                      debbi.ford@shire.com       +1 617 949 9083   

    NOTES TO EDITORS

    About Shire

    Shire is the leading global biotechnology company focused on serving people
    with rare diseases and other highly specialized conditions. We strive to
    develop best-in-class products, many of which are available in more than 100
    countries, across core therapeutic areas including Hematology, Immunology,
    Neuroscience, Ophthalmics, Lysosomal Storage Disorders, Gastrointestinal /
    Internal Medicine / Endocrine and Hereditary Angioedema; and a growing
    franchise in Oncology.

    Our employees come to work every day with a shared mission: to develop and
    deliver breakthrough therapies for the hundreds of millions of people in the
    world affected by rare diseases and other high-need conditions, and who lack
    effective therapies to live their lives to the fullest.

    www.shire.com