Director/PDMR Shareholding

    February 17, 2017 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company")

    Notification of transactions by person discharging managerial responsibilities

    1.   Details of the person discharging managerial responsibilities       
         ("PDMR") / person closely associated with them ("PCA")              
                                                                             
    a)   Name              Kim Stratton                                      
                                                                             
    2.   Reason for the notification                                         
                                                                             
    a)   Position / status Head of International Commercial - PDMR           
                                                                             
    b)   Initial           Amendment to prior notification to include the    
         notification /    automatic disposal of Ordinary Shares, as omitted 
         amendment         from the initial notification due to a            
                           transcription error, related to the automatic     
                           exercise of an option as detailed in the initial  
                           notification.                                     
                                                                             
    3.   Details of the issuer, emission allowance participant, auction      
         platform, auctioneer or auction monitor                             
                                                                             
    a)   Name              Shire plc                                         
                                                                             
    b)   LEI               54930005LQRLI2UXRQ59                              
                                                                             
    4.   Details of the transaction(s): section to be repeated for (i) each  
         type of instrument; (ii) each type of transaction; (iii) each date; 
         and (iv) each place where transactions have been conducted          
                                                                             
    a)   Description of    Shire plc Ordinary Shares of 5 pence each         
         the financial     ("Ordinary Shares")                               
         instrument, type                                                    
         of instrument                                                       
                                                                             
         Identification    ISIN: JE00B2QKY057                                
         code                                                                
                                                                             
    b)   Nature of the     Automatic exercise of option over notional        
         transaction       Ordinary Shares granted under the Shire Global    
                           Employee Stock Purchase Plan on November 1, 2015, 
                           and consequent receipt of Ordinary Shares.        
                                                                             
    c)   Price(s) and              Price(s)                 Volume(s)        
         volume(s)                                                           
                                    £40.70                     244           
                                                                             
    d)   Aggregated        N/A (single transaction)                          
         information                                                         
                                                                             
    e)   Date of the       October 31, 2016                                  
         transaction                                                         
                                                                             
    f)   Place of the      N/A                                               
         transaction                                                         
                                                                             
    5.   Details of the transaction(s): section to be repeated for (i) each  
         type of instrument; (ii) each type of transaction; (iii) each date; 
         and (iv) each place where transactions have been conducted          
                                                                             
    a)   Description of    Shire plc Ordinary Shares of 5 pence each         
         the financial     ("Ordinary Shares")                               
         instrument, type                                                    
         of instrument                                                       
                                                                             
         Identification    ISIN: JE00B2QKY057                                
         code                                                                
                                                                             
    b)   Nature of the     Automatic disposal of Ordinary Shares related to  
         transaction       the automatic option exercise referenced in       
                           section 4. above. The proceeds of this disposal   
                           were used to satisfy personal tax liabilities     
                           arising from the option exercise.                 
                                                                             
    c)   Price(s) and              Price(s)                 Volume(s)        
         volume(s)                                                           
                                    £46.07                      9            
                                                                             
    d)   Aggregated        N/A (single transaction)                          
         information                                                         
                                                                             
    e)   Date of the       October 31, 2016                                  
         transaction                                                         
                                                                             
    f)   Place of the      London Stock Exchange (XLON)                      
         transaction                                                         

    Oliver Strawbridge

    Senior Assistant Company Secretary

    For further information please contact:

    Investor Relations                                                           
                                                                                 
    Ian Karp                        ikarp@shire.com            +1 781 482 9018   
                                                                                 
    Robert Coates                   rcoates@shire.com          +44 1256 894874   
                                                                                 
    Media                                                                        
                                                                                 
    Lisa Adler                      lisa.adler@shire.com       +1 617 588 8607   
                                                                                 
    Debbi Ford                      debbi.ford@shire.com       +1 617 949 9083   

    NOTES TO EDITORS

    About Shire

    Shire is the leading global biotechnology company focused on serving people
    with rare diseases. We strive to develop best-in-class products, many of which
    are available in more than 100 countries, across core therapeutic areas
    including Hematology, Immunology, Neuroscience, Ophthalmics, Lysosomal Storage
    Disorders, Gastrointestinal / Internal Medicine / Endocrine and Hereditary
    Angioedema; and a growing franchise in Oncology.

    Our employees come to work every day with a shared mission: to develop and
    deliver breakthrough therapies for the hundreds of millions of people in the
    world affected by rare diseases and other high-need conditions, and who lack
    effective therapies to live their lives to the fullest.

    www.shire.com