Shire to announce first quarter 2015 results

Dublin, Ireland - April 21, 2015 - Shire plc (LSE: SHP, NASDAQ: SHPG), will
announce first quarter 2015 earnings on Thursday April 30, 2015.

Results press release will be       12:00 BST / 07:00 EDT
issued at:

Investor conference call time:      14:00 BST / 09:00 EDT

Live conference call for investors:

Flemming Ornskov, Chief Executive Officer and Jeff Poulton, Interim Chief
Financial Officer will host the investor and analyst conference call at 14:00
BST/9:00 EDT.

The details of the conference call are as follows:

UK dial in:                   0808 237 0030 or 020 3139 4830

US dial in:                   1 866 928 7517 or 1 718 873 9077

International Access Numbers: http://wpc.1726.planetstream.net/001726/FEL_Events_International_Access_List.pdf

Password/Conf ID:             54094197#

Live Webcast:                 http://www.shire.com/shireplc/en/investors/presentations


Replay:

A replay of the presentation will be available for two weeks by phone and by
webcast for three months. Details can be found on our Investor Relations
website http://www.shire.com/shireplc/en/investors.

For further information please contact:

Investor Relations

Sarah Elton-Farr                        seltonfarr@shire.com +44 1256 894157

Notes to editors

Shire enables people with life-altering conditions to lead better lives.

Our strategy is to focus on developing and marketing innovative specialty
medicines to meet significant unmet patient needs.

We focus on providing treatments in Rare Diseases, Neuroscience,
Gastrointestinal and Internal Medicine and we are developing treatments for
symptomatic conditions treated by specialist physicians in other targeted
therapeutic areas, such as Ophthalmics.

www.shire.com


Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX

Press Release

www.shire.com