Total Voting Rights

April 1, 2014 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company"), in
accordance with the Financial Conduct Authority's (the "FCA") Disclosure and
Transparency Rule 5.6.1R, notifies the market of the following:

At close of business on March 31, 2014, the Company's issued ordinary share
capital comprised 588,893,971 ordinary shares of 5 pence each with voting
rights and a further 9,019,832 ordinary shares held in treasury.

Therefore the total number of voting rights in the Company is 588,893,971. This
is the figure which should be used by shareholders as the denominator for the
calculations by which they will determine if they are required to notify their
interest in, or a change to their interest in, the Company under the FCA's
Disclosure and Transparency Rules.

Tony Guthrie
Deputy Company Secretary


For further information please contact:

Investor Relations

Laurie Stelzer                          lstelzer@shire.com   +1 781 482 0733
Eric Rojas                              erojas@shire.com     +1 781 482 0999
Sarah Elton-Farr                        seltonfarr@shire.com +44 1256 894157


Notes to editors

Shire enables people with life-altering conditions to lead better lives.

Our strategy is to focus on developing and marketing innovative specialty
medicines to meet significant unmet patient needs.

We provide treatments in Neuroscience, Rare Diseases, Gastrointestinal and
Internal Medicine and we are developing treatments for symptomatic conditions
treated by specialist physicians in other targeted therapeutic areas.

Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX

Press Release

www.shire.com