BLOCK LISTING SIX MONTHLY RETURN November 24, 2014 - Shire plc (LSE: SHP, NASDAQ: SHPG) Name of applicant: Shire plc Name of scheme: 2000 Executive Share Option Scheme Period of return: From: May 23, 2014 To: November 22, 2014 Balance of unallotted securities under 3,406,623 scheme(s) from previous return: Plus: The amount by which the block Nil scheme(s) has been increased since the date of the last return (if any increase has been applied for): Less: Number of securities issued/ Nil allotted under scheme(s) during period (see LR3.5.7G): Equals: Balance under scheme(s) not 3,406,623 yet issued/allotted at end of period: Name of applicant: Shire plc Name of scheme: Shire Sharesave Scheme Period of return: From: May 23, 2014 To: November 22, 2014 Balance of unallotted securities under 210,392 scheme(s) from previous return: Plus: The amount by which the block Nil scheme(s) has been increased since the date of the last return (if any increase has been applied for): Less: Number of securities issued/ 2,634 allotted under scheme(s) during period (see LR3.5.7G): Equals: Balance under scheme(s) not 207,758 yet issued/allotted at end of period: Name of applicant: Shire plc Name of scheme: Portfolio Share Plan Period of return: From: May 23, 2014 To: November 22, 2014 Balance of unallotted securities under 1,594,259 scheme(s) from previous return: Plus: The amount by which the block Nil scheme(s) has been increased since the date of the last return (if any increase has been applied for): Less: Number of securities issued/ 456,045 allotted under scheme(s) during period (see LR3.5.7G): Equals: Balance under scheme(s) not 1,138,214 yet issued/allotted at end of period: Name of applicant: Shire plc Name of scheme: Employee Stock Purchase Plan Period of return: From: May 23, 2014 To: November 22, 2014 Balance of unallotted securities under 422,301 scheme(s) from previous return: Plus: The amount by which the block 500,000 scheme(s) has been increased since the date of the last return (if any increase has been applied for): Less: Number of securities issued/ 397,591 allotted under scheme(s) during period (see LR3.5.7G): Equals: Balance under scheme(s) not 524,710 yet issued/allotted at end of period: Name of contact: Tony Guthrie, Deputy Company Secretary Address of contact: Hampshire International Business Park Basingstoke, Hampshire, RG24 8EP Telephone number of contact: 01256 894746 For further information please contact: Investor Relations Jeff Poulton jpoulton@shire.com +1 781 482 0945 Sarah Elton-Farr seltonfarr@shire.com +44 1256 894157 NOTES TO EDITORS Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialty medicines to meet significant unmet patient needs. We focus on providing treatments in Neuroscience, Rare Diseases, Gastrointestinal, and Internal Medicine and we are developing treatments for symptomatic conditions treated by specialist physicians in other targeted therapeutic areas, such as Ophthalmology. www.shire.com Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX Press Release www.shire.com
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