Morgan Stanley & Co. LLC

AMENDMENT (Section 2(a))

FORM 8.5 (EPT/RI)

PUBLIC DEALING DISCLOSURE BY AN EXEMPT PRINCIPAL TRADER WITH RECOGNISED INTERMEDIARY STATUS DEALING IN A CLIENT-SERVING CAPACITY

Rule 8.5 of the Takeover Code (the "Code")

1. KEY INFORMATION

(a) Name of exempt principal trader:

Morgan Stanley & Co. LLC

(b) Name of offeror/offeree in relation to whose relevant securities this form relates:

Use a separate form for each offeror/offeree

ABBVIE INC

(c) Name of the party to the offer with which exempt principal trader is connected:

SHIRE PLC

(d) Date dealing undertaken:

17 JULY 2014

(e) Has the EPT previously disclosed, or is it today disclosing, under the Code in respect of any other party to this offer?

Yes

2. DEALINGS BY THE EXEMPT PRINCIPAL TRADER

(a) Purchases and sales

Class of relevant security

Purchases/sales

Total number of securities

Highest price per unit paid/received

Lowest price per unit paid/received

COMMON STOCK

PURCHASES

224,000

30.9815 GBP

30.9815 GBP

COMMON STOCK

PURCHASES

3,318,275

54.9900 USD

52.8800 USD

COMMON STOCK

SALES

3,602,344

54.9900 USD

52.8900 USD

(b) Derivatives transactions (other than options)

Class of relevant security

Product description

e.g. CFD

Nature of dealing

e.g. opening/closing a long/short position, increasing/reducing a long/short position

Number of reference securities

Price per unit

N/A

N/A

N/A

N/A

N/A

(c) Options transactions in respect of existing securities

(i) Writing, selling, purchasing or varying

Class of relevant security

Product description e.g. call option

Writing, purchasing, selling, varying etc.

Number of securities to which option relates

Exercise price per unit

Type e.g. American, European etc.

Expiry date

Option money paid/ received per unit

COMMON STOCK

CALL

PURCHASE

1,000

55.0000

A

19/07/2014

0.2000 USD

COMMON STOCK

CALL

PURCHASE

5,000

55.0000

A

19/07/2014

0.2000 USD

COMMON STOCK

CALL

PURCHASE

1,800

57.5000

A

16/08/2014

0.5100 USD

COMMON STOCK

CALL

PURCHASE

1,000

52.5000

A

19/07/2014

0.8500 USD

COMMON STOCK

CALL

PURCHASE

100

52.5000

A

19/07/2014

0.8500 USD

COMMON STOCK

CALL

PURCHASE

100

52.5000

A

19/07/2014

0.8500 USD

COMMON STOCK

CALL

PURCHASE

100

52.5000

A

19/07/2014

0.8500 USD

COMMON STOCK

CALL

PURCHASE

100

52.5000

A

19/07/2014

0.8500 USD

COMMON STOCK

CALL

PURCHASE

500

52.5000

A

19/07/2014

0.9500 USD

COMMON STOCK

CALL

PURCHASE

500

52.5000

A

19/07/2014

0.9500 USD

COMMON STOCK

CALL

PURCHASE

100

52.5000

A

19/07/2014

0.9500 USD

COMMON STOCK

CALL

PURCHASE

1,100

55.0000

A

16/08/2014

1.0000 USD

COMMON STOCK

CALL

PURCHASE

2,000

55.0000

A

16/08/2014

1.0000 USD

COMMON STOCK

CALL

PURCHASE

1,100

55.0000

A

16/08/2014

1.0500 USD

COMMON STOCK

PUT

PURCHASE

1,100

52.5000

A

16/08/2014

1.3000 USD

COMMON STOCK

CALL

SALE

100

55.0000

A

19/07/2014

0.2000 USD

COMMON STOCK

CALL

SALE

200

55.0000

A

19/07/2014

0.2400 USD

COMMON STOCK

PUT

SALE

1,500

52.5000

A

19/07/2014

0.5000 USD

COMMON STOCK

PUT

SALE

5,900

52.5000

A

19/07/2014

0.5000 USD

COMMON STOCK

PUT

SALE

3,300

52.5000

A

19/07/2014

0.5000 USD

COMMON STOCK

PUT

SALE

2,000

52.5000

A

19/07/2014

0.5000 USD

COMMON STOCK

PUT

SALE

600

52.5000

A

19/07/2014

0.5000 USD

COMMON STOCK

PUT

SALE

4,900

52.5000

A

19/07/2014

0.5000 USD

COMMON STOCK

PUT

SALE

3,400

52.5000

A

19/07/2014

0.5000 USD

COMMON STOCK

PUT

SALE

100

52.5000

A

19/07/2014

0.5000 USD

COMMON STOCK

PUT

SALE

4,500

52.5000

A

19/07/2014

0.5000 USD

COMMON STOCK

PUT

SALE

1,800

52.5000

A

19/07/2014

0.5000 USD

COMMON STOCK

CALL

SALE

1,100

57.5000

A

16/08/2014

0.5500 USD

COMMON STOCK

CALL

SALE

1,100

57.5000

A

16/08/2014

0.5500 USD

COMMON STOCK

CALL

SALE

600

57.5000

A

16/08/2014

0.5500 USD

COMMON STOCK

PUT

SALE

100

55.0000

A

19/07/2014

1.1300 USD

COMMON STOCK

PUT

SALE

1,200

45.0000

A

17/01/2015

1.2500 USD

COMMON STOCK

PUT

SALE

100

45.0000

A

17/01/2015

1.2500 USD

COMMON STOCK

PUT

SALE

1,000

52.5000

A

16/08/2014

1.6000 USD

COMMON STOCK

PUT

SALE

900

47.5000

A

17/01/2015

1.9000 USD

COMMON STOCK

CALL

SALE

100

52.5000

A

16/08/2014

2.3500 USD

(ii) Exercising

Class of relevant security

Product description e.g. call option

Number of securities

Exercise price per unit

N/A

N/A

N/A

N/A

(d) Other dealings (including subscribing for new securities)

Class of relevant security

Nature of dealing e.g. subscription, conversion

Details

Price per unit (if applicable)

N/A

N/A

N/A

N/A

The currency of all prices and other monetary amounts should be stated.

Where there have been dealings in more than one class of relevant securities of the offeror or offeree named in 1(b), copy table 2(a), (b), (c) or (d) (as appropriate) for each additional class of relevant security dealt in.

3. OTHER INFORMATION

(a) Indemnity and other dealing arrangements

Details of any indemnity or option arrangement, or any agreement or understanding, formal or informal, relating to relevant securities which may be an inducement to deal or refrain from dealing entered into by the exempt principal trader making the disclosure and any party to the offer or any person acting in concert with a party to the offer:

If there are no such agreements, arrangements or understandings, state "none"

None

(b) Agreements, arrangements or understandings relating to options or derivatives

Details of any agreement, arrangement or understanding, formal or informal, between the exempt principal trader making the disclosure and any other person relating to:

(i) the voting rights of any relevant securities under any option; or

(ii) the voting rights or future acquisition or disposal of any relevant securities to which any derivative is referenced:

If there are no such agreements, arrangements or understandings, state "none"

None

Date of disclosure:

28 JULY 2014

Contact name:

Darren Wickert

Telephone number:

+44 (0)20 7425 6578

Public disclosures under Rule 8 of the Code must be made to a Regulatory Information Service and must also be emailed to the Takeover Panel atmonitoring@disclosure.org.uk. The Panel's Market Surveillance Unit is available for consultation in relation to the Code's dealing disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel's website atwww.thetakeoverpanel.org.uk.


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