- Univercells to test proprietary mRNA vaccine delivered with Altamira’s SemaPhore™ nanoparticles
- Targeting safer and accessible mRNA vaccines
Under the terms of the agreement, Univercells will test in vitro and in vivo a proprietary mRNA vaccine delivered with Altamira’s SemaPhore nanoparticle platform. Should the experiments prove successful, Univercells and Altamira intend to discuss and negotiate a commercial agreement for the development and manufacturing of nanoparticle-based mRNA vaccines using Univercells’ production platform.
“We are thrilled to initiate this collaboration with Univercells to explore SemaPhore as a delivery vehicle for mRNA vaccines”, commented Covadonga Pañeda, PhD, Altamira’s Chief Operating Officer. “SemaPhore has shown to be an efficient delivery vehicle for therapeutic RNA in many different disease models. With this collaboration we will explore for the first time its potential utility in delivering mRNA vaccines. Current delivery vehicles used in the field of mRNA vaccines suffer from significant rates of mRNA loss during cell entrance; in addition, they may cause local or systemic side effects. SemaPhore reduces mRNA loss during cell entrance, which may allow for using lower doses. This feature, together with its favorable tolerability profile could make SemaPhore a compelling alternative to conventional delivery vehicles.”
“We’re delighted to be partnering with Altamira to explore better ways to deliver mRNA to patients,” said
mRNA vaccines work through priming the body’s immune system to recognize and destroy a pathogen. The vaccines introduce a small piece of the target pathogen’s proteins into specialized cells in our bodies that can produce the full protein. These cells then manufacture the target protein in small amounts triggering the production of specific antibodies to destroy any entity that has the same protein, such as a virus. Although our bodies break down the vaccine’s mRNA very quickly, the antibodies linger so that we are protected should we contract the virus in the future.
About SemaPhore
SemaPhore is a versatile platform designed to enable safe and effective delivery of mRNA into target cells, using systemic or local administration. It is based on a proprietary 21 amino acid peptide that can engage any type of RNA in rapid self-assembly into a polyplex. The polyplex has a size, charge, and other physical features that allow it to escape hepatic clearance and thus to reach target tissues other than the liver. SemaPhore protects the RNA payload from degradation in the circulation and allows for rapid and effective cell entrance. Efficient delivery and positive treatment outcomes have been demonstrated in multiple murine models of disease so far.
About
About Univercells
Univercells is a global life sciences company with the mission of making biologics accessible. Using our combined expertise in scaling, production and bioprocessing, Univercells finds new and sustainable ways to widen access to life-changing drugs. Our affiliate companies deploy innovations in infrastructure, drug substance manufacturing, equipment manufacturing, equipment design, training, and on-the-ground health services to drive down costs, shrink manufacturing footprints and meet the needs of the entire health value chain. Headquartered in Jumet (
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