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A new study, the fourth and most comprehensive in a series of four (1), reconfirms that acute stress increases the overproduction of the powerful neurosteroid Allopregnanolone in the medial prefrontal cortex (mPFC) of the brain, and that the administration of its endogenous modulator isoallopregnanolone (being developed as the novel treatment Sepranolone) counters those effects. The study, Acute stress impairs sensorimotor gating via the neurosteroid allopregnanolone in the prefrontal cortex, was carried out by Professor
Positive PPI findings - a key metric in Tourette, OCD and schizophrenia
The study significantly strengthened evidence that increased production of ALLO reduces Prepulse Inhibition (PPI), the universal ability to reduce the startle reflex in response to repeated stressors. PPI is a key metric used in clinical tests for Tourette, OCD, schizophrenia and others. With reduced PPI, Tourette patients, for example, are unable to manage their startle response and react with the same level of startle to the same, repeated stressor. The current and very solid study demonstrates i) ALLO's harmful effect on PPI from four different kinds of stress triggers tested in three different breeds of rodents, and ii) how both systemic and intra-PFC administration of isoallopregnanolone (Sepranolone) countered that negative effect.
Broader study increases translatability
The study significantly increased the number and range of subjects and stress stimuli in comparison to previous studies. It tested four very different types of stress factors on three different breeds of rodents. This significantly increases the Translatability of these and earlier findings: "The confirmation of these mechanisms across distinct animal models and several different acute stressors strongly supports the translational value of these findings and warrants future research on the role of ALLO in information processing." (2)
Tourette and Sepranolone
Previous preclinical studies carried out by the
- 2017, https://www.nature.com/articles/s41598-017-03649-1 2019 https://pubmed.ncbi.nlm.nih.gov/31175669/ 2022 https://pubmed.ncbi.nlm.nih.gov/34423500/
- https://www.sciencedirect.com/science/article/pii/S2352289522000649
For further information, please contact:
Peter Nordkild, CEO,
Phone: +45 25 47 16 46
E-mail: peter.nordkild@asarinapharma.com
About
We are a Swedish biotech company developing Sepranolone for allopregnanolone-induced stress- and compulsivity-driven disorders. Our product pipeline is built on over 40 years of research into allopregnanolone-related neurological disorders. With our new family of GAMSA compounds (GABA-A Modulating Steroid Antagonists) we aim to deliver a new generation of safe, efficacious drugs for neurological conditions from Tourette syndrome to Obsessive Compulsive Disorder that still lack safe, efficacious pharmaceutical treatments.
https://news.cision.com/asarina-pharma/r/extensive-new-preclinical-study-significantly-increases-the-translatability-of-asarina-pharma-s-find,c3643542
https://mb.cision.com/Main/17069/3643542/1635175.pdf
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