The Board of Directors (the ?Board?) of BioDelivery Sciences International had appointed John Golubieski as the Company?s Chief Accounting Officer, effective as of October 25, 2021. Mr. Golubieski will serve as Chief Accounting Officer until November 4, 2021, at which time he will resign from the position of Chief Accounting Officer and become Chief Financial Officer. Mr. Golubieski will also serve as the Company?s principal financial officer and principal accounting officer, effective as of November 4, 2021. Prior to joining the Company, from May 2018 to April 2020, Mr. Golubieski, 56, served as Chief Financial Officer of IlluminOss Medical, Inc., a medical device company, prior to its acquisition by a private equity firm. From August 2017 to May 2018, Mr. Golubieski served as Chief Financial Officer of Axsome Therapeutics, Inc., a biopharmaceutical company. From June 2014 to August 2017, Mr. Golubieski served as Chief Financial Officer of Osmotica Holdings, LLC, a biopharmaceutical company. From July 2013 to June 2014, Mr. Golubieski served as Interim Chief Financial Officer of Lantheus Medical Imaging, Inc., a public medical diagnostic company, which he helped complete its initial public offering. On October 15, 2021, Mary Theresa Coelho resigned as Executive Vice President and Treasurer of the Company to pursue other professional opportunities. Ms. Coelho?s resignation is effective as of November 3, 2021 and is not the result of any disagreement regarding the Company?s financial reporting or accounting policies, procedures, estimates or judgments.