C4 Therapeutics, Inc. announced that on June 15, 2022, Alain J. Cohen, a member of the Board and a nominee for election as a director at the 2022 Annual Meeting, notified the Board of his withdrawal as a director nominee for re-election at the 2022 Annual Meeting. Mr. Cohen's withdrawal as a director nominee does not arise from any disagreement on any matter relating to the Company's strategy, operations, policies or practices. Mr. Cohen will cease to serve as a director of the Company on June 22, 2022.

The Board has determined that it will not nominate a replacement director for election at the 2022 Annual Meeting.