The research presented was conducted by CLS and our partner
The results were achieved by demonstrating safe and highly efficient use of CLS TRANBERG® non-cooled laser applicators in porcine brain. The laser light caused thermal damage in the target tissue leading to coagulative necrosis and finally to cell death. Thermoguide™ thermometry software estimated the thermal damage and provided color-coded Thermal Damage Thresholds that predicted irreversible tissue damage, and clearly delineated safety margins to eloquent brain structures. Additional results were achieved by evaluating the accuracy of temperature prediction by Thermoguide compared to calibrated temperature probes in vivo, and by histology of the brain tissue after 3 days survival.
The authors conclude that Thermoguide provided an accurate near-real-time temperature map of the brain tissue, demonstrated by high correlation between Thermoguide thermometry and physical temperature probes. Dimensions and location of the irreversible tissue damage estimate, as visualized by the software, agreed well with histopathology.
"The safety and efficacy of the Thermoguide software demonstrated in this in vivo porcine model was essential for our full FDA 510(k) clearance in neurosurgery", says
Currently, a CLS-sponsored clinical study is ongoing at Skåne
1Singh et al. Preclinical assessment of a noncooled MR thermometry-based neurosurgical laser therapy system. J Neurosurg. Published online
For more information, please contact:
Dan J Mogren, CEO,
Phone: +46 (0) 70-590 11 40
E-mail: dan.mogren@clinicallaser.com
Website: www.clinicallaser.se
About CLS
For more information about CLS, please visit the Company's website: www.clinicallaser.se
https://news.cision.com/cls/r/publication-in-journal-of-neurosurgery-demonstrates-distinct-advantages-of-cls-s-core-technology-in-,c3943806
https://mb.cision.com/Main/11591/3943806/2660274.pdf
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