Compugen Ltd. announced that it will present pre-clinical data on its lead pre-clinical asset COM503 in an oral presentation at the 20th CIMT annual meeting, Europe's Cancer Immunotherapy Meeting, on May 3-5, 2023, in Mainz, Germany. During its oral presentation at CIMT company will present pre-clinical data showing that COM503 binds with high affinity to IL-18 binding protein, freeing IL-18 and restoring NK and T cell activity. The company will also show that blocking IL-18 binding protein prevents tumor growth and releases IL-18 to activate immunity in the TME without affecting peripheral immunity in murine tumor models.

This is a differentiated approach to harness cytokine biology for cancer therapeutics.