The use of MSC as a potential treatment for tissue regeneration, inflammatory and regenerative diseases has been the subject of increasing interest in the global scientific community. Osteoarthritis of the knee is a debilitating disease affecting Singapore’s aging population and the clinical trial will pioneer stem cell use for regenerative medicine in
UC-MSCs are a type of adult stem cells that can be isolated from the umbilical cord tissue after childbirth. These cells possess unique properties that have demonstrated to be promising for various therapeutic applications, especially when these cells are freshly harvested and isolated from the umbilical cord, as compared to MSCs derived from frozen tissues, of which the yield and quality may potentially suffer. UC-MSCs are considered multipotent and are able to differentiate into different cell types, including bone, cartilage, fat, and muscle cells. They also exhibit immunomodulatory and anti-inflammatory properties, making them attractive for regenerative medicine and immune-related disorders.
"Our collaboration with CytoMed marks a significant step in advancing research on allogeneic in-vivo UC-MSC for cartilage repair, including osteoarthritis of the knee. Through our commitment to the Investigator Initiated Trial (IIT), we aim to gather crucial safety and efficacy data and evidence to make this intervention more accessible to patients," said Assistant Professor
“The unique advantages of UC-MSCs include their abundant supply, compared to cord blood-derived MSCs or adult stem cell sources like bone marrow-derived MSCs. Freshly harvested UC-MSCs are believed to possess higher proliferation capacity and greater differentiation potential. Additionally, UC-MSCs have been shown to exhibit lower immunogenicity and are less likely to be rejected by the recipient’s immune system, which opens the possibility for allogeneic (donor-to-recipient) transplantation. Therefore, UC-MSC would serve as an ideal source of regenerative cells for treating osteoarthritis of the knee. This hypothesis has also been supported by many international published clinical papers. We are excited to embark on this collaboration, which would potentially be the first stem cell trial in Singapore,” added
Under the RCA, CytoMed will provide the allogeneic UC-MSC, processed and expanded in its own state-of-the-art GMP laboratory while SKH will provide the infrastructure, manpower and scientific data analysis.
CytoMed is focused on cancer immunotherapies. The RCA has been established within a year of approval of CytoMed’s Phase 1 IIT with the
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Incorporated in 2018, CytoMed was spun off from the
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