Kite Cell Therapy

A n a l y s t & I n v e s t o r E v e n t 1 4 M a r c h 2 0 2 4

FOR INVESTOR USE ONLY; NOT FOR PROMOTIONAL USE

Forward-Looking Statements

Statements included in this presentation that are not historical in nature are forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Gilead cautions readers that forward-looking statements are subject to certain risks and uncertainties that could cause actual results to differ materially. These risks and uncertainties include those relating to: Gilead and Kite's ability to achieve its anticipated full year 2024 financial results, including as a result of the uncertainty of the amount and timing of Veklury sales and any potential impairment charges related to our Phase 3 EVOKE-01study; Gilead's ability to make progress on any of its long-term ambitions or strategic priorities laid out in its corporate strategy, including Kite's ability to make

progress on any of its long-term ambitions or strategic priorities laid out in this presentation, including strategies relating to Kite's commercial, manufacturing, clinical development and research functions; Gilead's ability to accelerate or sustain revenues for its virology, oncology and other programs; Gilead's ability to realize the potential benefits of acquisitions, collaborations or licensing arrangements, including Gilead's ability to identify suitable transactions as part of its business strategy and the risk that Gilead may not be able to complete any such transaction in a timely manner or at all, including the possibility that a governmental entity or regulatory body may delay or refuse to grant approval for the consummation of the transaction; Gilead's ability to initiate, progress or complete clinical trials within currently anticipated timeframes or at all, the possibility of unfavorable results from ongoing and additional clinical trials and the risk that safety and efficacy data from clinical trials may not warrant further development of Gilead's product candidates or the product candidates of Gilead's strategic partners; Gilead's ability to submit new drug applications for new product candidates or expanded indications in the currently anticipated timelines; Gilead's ability to receive regulatory approvals in a timely manner or at all, and the risk that any such approvals may be subject to significant limitations on use; Gilead's ability to successfully commercialize its products; the risk of potential disruptions to the manufacturing and supply chain of Gilead's products; pricing and reimbursement pressures from government agencies and other third parties, including required rebates and other discounts; a larger than anticipated shift in payer mix to more highly discounted payer segments; market share and price erosion caused by the introduction of generic versions of Gilead products; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; and other risks identified from time to time in Gilead's reports filed with the SEC, including annual reports on Form 10-K, quarterly reports on Form 10-Q and current reports on Form 8-K. In addition, Gilead makes estimates and judgments that affect the reported amounts of assets, liabilities, revenues and expenses and related disclosures. Gilead bases its estimates on historical experience and on various other market specific and other relevant assumptions that it believes to be reasonable under the circumstances, the results of which form the basis for making judgments about the carrying values of assets and liabilities that are not readily apparent from other sources. There may be other factors of which Gilead is not currently aware that may affect matters discussed in the forward-looking statements and may also cause actual results to differ significantly from these estimates. Gilead directs readers to its press releases, annual reports on Form 10-K, quarterly reports on Form 10-Q and other subsequent disclosure documents filed with the SEC. Gilead claims the protection of the Safe Harbor contained in the Private Securities Litigation Reform Act of 1995 for forward-looking statements.

The reader is cautioned that forward-looking statements are not guarantees of future performance and is cautioned not to place undue reliance on these forward-looking statements. All forward- looking statements are based on information currently available to Gilead and Gilead assumes no obligation to update or supplement any such forward-looking statements other than as required by law. Any forward-looking statements speak only as of the date hereof or as of the dates indicated in the statements.

Gilead owns or has rights to various trademarks, copyrights and trade names used in its business, including the following: GILEAD®, GILEAD SCIENCES®, KITETM, AMBISOME®, ATRIPLA®, BIKTARVY®, CAYSTON®, COMPLERA®, DESCOVY®, DESCOVY FOR PREP®, EMTRIVA®, EPCLUSA®, EVIPLERA®, GENVOYA®, HARVONI®, HEPCLUDEX®, HEPSERA®, JYSELECA®, LETAIRIS®, ODEFSEY®, SOVALDI®, STRIBILD®, SUNLENCA®,TECARTUS®, TRODELVY®, TRUVADA®, TRUVADA FOR PREP®, TYBOST®, VEKLURY®, VEMLIDY®, VIREAD®, VOSEVI®, YESCARTA® and ZYDELIG®. This report may also refer to trademarks, service marks and trade names of other companies.

Throughout this presentation, investigational products and programs that are part of Gilead's pipeline are discussed. Please note that these investigational products or uses are not approved by the FDA, and their safety and efficacy have not been established. For more information about Gilead's approved products referenced in the presentation, please view the full U.S. Prescribing Information, available on Gilead.com

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"Having an incurable cancer, you think about it every day." Laurie, diagnosed with non- Hodgkin lymphoma

Welcome to Kite

C i n d y P e r e t t i e

E V P & H e a d o f K i t e

Kite Analyst Event: Global Leader in Cell Therapy

Leading Commercial Execution

Setting the Industry Manufacturing Standard

Investing Today to Maintain Leadership Tomorrow

  • Building best-in-class commercial capabilities and extending leadership
  • Driving differentiation vs in-class and out-of-class competitors
  • Building class share with ATC growth & innovative model of community expansion
  • Expand access globally and further demonstrate the value of CAR T
  • 96% manufacturing success allows more patients to receive cells the first time
  • Rapid 14-day turnaround time in U.S. with opportunities for further improvements
  • Moving towards full automation to enable greater capacity and cost efficiencies
  • Executing plans for anito-cel manufacturing to support commercial launch
  • Winning in multiple myeloma with potentially best-in-classanito-cel
  • Potentially expanding Yescarta into the front-line setting for high-risk LBCL
  • Advancing next-generation constructs across auto, allo and in vivo
  • Leveraging cell therapy expertise to identify the right autoimmune approach

5

Initial Impressions - Fall 2023

Commercial

Manufacturing

Broad Pipeline

Execution

Excellence

Key Opportunities

1

2

3

4

5

Cell Therapy

Academic &

Multiple

Cell Therapy

Research &

Class Share

Community Setting

Myeloma

Beyond Oncology

Translational

Science

Reinforce Robust,

Deepen & Expand

Develop & Launch

Expand Curative

Leverage Internal

Long-Term Data,

ATC Reach

Potentially Best-in-Class

Potential of Cell Therapy

Expertise to Advance

Manufacturing

Anito-cel

Next Gen Kite CAR T

Excellence & Global

Technology

Footprint

Drive, Innovation and Collaboration

6

Setting the Standard for Cell Therapy

Market Presence

Investment

ATC network and commercial model to provide patients, physicians, and institutions end-to-end support

Result

Unrivaled patient reach across 420+ ATCs in 25+ countries

Manufacturing and

Supply Chain

Excellence

Investment

Four commercial manufacturing facilities, including a commercial viral vector facility

Result

Industry-leading14-day turnaround time1 and 96% manufacturing success rate

Specialized Clinical

Development

Investment

Strategically designed studies and focus on long-term data generation

Result

Kite's ZUMA studies are the benchmark in lymphoma, and we are working towards the same in myeloma

Internal T-Cell

Expertise

Investment

The largest clinical and real- world experience database in the industry, with 19,500+ treated patients to date

Result

Allows Kite to successfully build a next-gen pipeline in lymphoma and beyond

1. Median for Yescarta in the U.S.

Kite's leadership reflects early investment and commitment to establishing key capabilities

7

Continued Cell Therapy Leadership Ambitions

30+

15+

Countries

40%+

Indications

Class Share2

150K+

3-day

Patients

Manufacturing

Treated1

TAT

1. Of hematologic cancers 2. Of eligible population using CAR T-cell therapy.

Increase curative potential to reach more eligible patients

8

Advancing Portfolio into $40B+ Markets

Kite Sales

$1.9B

Future Cell Therapy Market Potential1

$1.5B

Lymphoma & Leukemia

Multiple Myeloma

$10B - $12B

$15B - $20B

$0.9B

$0.6B

Autoimmune

Solid Tumors

$15B - $20B

1. 2034 estimate.

2020

2021

2022

2023

Significant market opportunities across existing & future indications

9

Strategic Priorities to Deliver on Ambitions

Grow Kite's Best-in-

Capitalize on Kite's

Position Kite for

Deploy a

Class Autologous

CAR T Leadership in

Next Gen Auto and

Fit-for-Purpose

Platform

Clinically Ready Areas

Potential Pivots

Organization

Increase Healthcare

Next Gen Lymphoma,

Examples Include:

Focus on People,

System Capacity, Reduce

Multiple Myeloma,

Solid Tumors,

Culture and Financial

COGS and Grow Class

and Autoimmune

Allogenic and in vivo

Discipline

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Gilead Sciences Inc. published this content on 14 March 2024 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 14 March 2024 22:40:01 UTC.