On May 25, 2018, each of Drs. Alexandria Forbes and Thomas Shenk announced Kadmon Holdings, Inc. of their resignation as a director of the company effective as of the date the registration statement of MeiraGTx Holdings plc is declared effective. Dr. Forbes and Dr. Shenk are resigning to focus on their responsibilities as the Chief Executive Officer and Director, and Director, respectively, of Meira GTx Holdings plc, in which the company has an approximately 17% ownership stake as of the date hereof, and which is currently considering an initial public offering.