Kuros Biosciences

The future of spinal fusions

Investor Webcast - H1 2023 Earnings and Operational Update August 23, 2023

1

Disclaimer

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Market data and other statistical information used throughout this presentation are based on industry publications and surveys, reports by market research firms or other published independent sources. Some data is based on the Company's internal estimates which are derived from the review of internal surveys, as well as the independent sources. The Company's estimates, in particular as they relate to market share and the Company's general expectations, involve risks and uncertainties and are subject to change based on various factors. Although the Company believes these sources are reliable, it has not independently verified the information and no representation or warranty, express or implied, is made as to, and no reliance should be placed on, the fairness, accuracy, completeness or correctness of the information or opinions expressed herein. The Company and its subsidiaries, managers, directors, officers, employees, agents or advisors shall have no liability whatsoever (in negligence or otherwise) for any loss howsoever arising from any use of this presentation or its contents or otherwise arising in connection with this presentation. The information

and opinions contained in this presentation do not purport to be comprehensive, are provided as at the date of this presentation and are subject to change without notice.

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This presentation shall not constitute an offer to sell or the solicitation of an offer to buy securities of the Company, in any jurisdiction in which such offer or solicitation would be unlawful prior to registration, exemption from registration or qualification under the securities laws of any jurisdiction.

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Corporate highlights

Swiss-headquartered biotech company with operations in the Netherlands and US. Listed on the SIX Swiss Stock Exchange (Ticker: KURN)

Strong financial foundation:

• Cash at ~$18.1M1, with a runway beyond Q3 2024

• ~126% revenue growth2 and potential $21.3M milestone payments + up to $142M sales milestone payments

Over 300+ Publications and 10+ active clinical studies. Strong global network of KOLs

MagnetOs surface modified biologics portfolio launched globally. Addressing $1B+ market opportunity. Targeting $100M annual sales within 5 years

Approx revenue from product sales (000s, USD)

1,386

2,936

3,865

5,060

6,104

8,106

13,834

H1

H2

H1

H2

H1

H2

H1

20

20

21

21

22

22

23

Strong start into 2023: 148% increase in direct MagnetOs sales in H1 2023 compared to H1 2022 Total revenue from medical devices rose from US$6.1M to US$13.8M

Fibrin-PTH phase 2 (under IND) in lumbar spinal fusion de- risked by two successfully completed phase 2 studies in the trauma indication

References: 1. Cash and cash equivalents CHF 16.9 million translated at CHF/USD (0.93) as of June 30, 2023. 2. Product sales CHF 12.9 million in H1-2023 compared to CHF 5.7 million in H1-2022 translated at CHF/USD (0.93).

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MagnetOs: Overview of clinical studies

Prospective clinical studies

Fully

Interim

Primary

Study

Study design Initiated

enrolled

results

endpoint

MAXA

Q4 '23

PARTNER

Q4 '23

PROOF

Q2 '24

PRECISE

Q2 '24

Results from an ongoing prospective clinical trial

R

Coronal fine-cut CT scans at one-yearfollow-up.

3D reconstruction at one-yearfollow-up.

MagnetOs Granules implanted on right hand side

Blue: Fusion w/ MagnetOs Granules; Gray: Autograft;

of patient, leading to solid spinal fusion.

Light Gray: Instrumentation.

  • Data from one randomized controlled trial shows fusion rate for MagnetOs of 78%, compared to 42% for the gold standard bone graft (autograft) *†1
  • Compares favorably to fusion rates of 55-71% reported for other synthetic bone grafts evaluated in similar posterolateral fusion trials 2, 3

References: 1. Data on file. 2. Lehr, et al. Spine. 2020; 45(14):944-951.3. Coughlan, et al. Spine (Phila Pa 1976). 2018;1-43(15):E860-E868. *Preliminary results from an ongoing trial.

MagnetOs Granules is cleared for standalone use in the posterolateral spine. Please refer to the Instructions for Use for a full list of indications, contraindications, precautions and warnings.

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Fibrin-PTH phase 2: STRUCTURE

DesignMethods

Primary endpoint

Study sites

  • Prospective, randomized controlled single blind multi- center study which intends to demonstrate safety and efficacy of Fibrin-PTH(KUR-113) versus local autograft
  • 50 patients in two stages (2 dose levels vs local autograft)
  • Randomized-stage(n=30) and second non-randomized stage (n=20) with higher dose fully enrolled July 2023
  • Single-levelTLIF with Fibrin- PTH or local autograft added in and around any static FDA cleared monoblock PEEK cage
  • Posterior lumbar fusion (PLF) (fixation plus MagnetOs Putty)
  • Radiological fusion determined by CT-scans and assessed by IREP at 12 months
  • Patients enrolled in 15 study sites
  • Includes strategic research centers such as BWH, HSS, UCSD, Northwestern, Medstar Georgetown

5 [Confidential]

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Kuros Biosciences AG published this content on 23 August 2023 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 23 August 2023 07:15:01 UTC.