Item 2.03 Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant.

On September 16, 2022, Non-Invasive Monitoring Systems, Inc. ("NIMS") entered into a Promissory Note in the principal amount of $75,000.00 with Frost Gamma Investments Trust (the "Frost Gamma Note"), a trust controlled by Dr. Phillip Frost, which beneficially owns in excess of 10% of NIMS' common stock. The interest rate payable by NIMS on the Frost Gamma Note is 11% per annum, payable on the maturity date of October 4, 2023 (the "Maturity Date"). The Frost Gamma Note may be prepaid in advance of the Maturity Date without penalty.

The foregoing is only a brief summary of some of the terms of the Frost Gamma Note and does not purport to be complete. Please refer to the Frost Gamma Note, which is attached as Exhibit 10.1 for its full terms.

On September 16, 2022, NIMS entered into a Promissory Note in the principal amount of $75,000.00 with Jane Hsiao, Ph.D., the Company's Chairman and Interim CEO (the "Hsiao Note") and a beneficial holder in excess of 10% of NIMS' common stock. The interest rate payable by NIMS on the Hsiao Note is 11% per annum, payable on the Maturity Date. The Hsiao Note may be prepaid in advance of the Maturity Date without penalty.

The foregoing is only a brief summary of some of the terms of the Hsiao Note and does not purport to be complete. Please refer to the Hsiao Note, which is attached as Exhibit 10.2 for its full terms.

Item 9.01 Financial Statements and Exhibits.

(d) Exhibits

10.1 Promissory Note of Non-Invasive Monitoring Systems, Inc. in favor of

Frost Gamma Investments Trust dated September 16, 2022

10.2 Promissory Note of Non-Invasive Monitoring Systems, Inc. in favor of Jane

Hsiao, dated September 16, 2022

104 Cover Page Interactive Data File (embedded within the Inline XBRL

document)

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