Vancouver, B.C. - Northisle Copper and Gold Inc. (TSX-V:NCX) ('Northisle' or the 'Company') is pleased to provide a review of its 2022 accomplishments in building a Leading Sustainable Resource Company as well as an overview of upcoming catalysts and Q1 2023 investor events.

2022 HIGHLIGHTS

CORPORATE

$7 million in flow-through funding raised, with Northisle one of the first companies in Canada to take advantage of the new Canadian Critical Minerals Exploration Tax Credit

Northisle joined the BC Regional Mining Alliance, a joint provincial, First Nations and industry forum for advancing BC mineral projects

Northisle amplified its board capabilities and enhanced diversity with the addition of Keena Hicken-Gaberria, who brings her governance, finance and business experience to the team

Ian Chang hired as Vice President Project Development to bring his extensive project development experience to the North Island Project

Dale Corman, Chairman of Northisle, inducted to the Canadian Mining Hall of Fame

PROJECT

Northisle signed an agreement with Quatsino First Nation which provides for an open, honest, transparent and fair process through which its subsidiary, North Island Mining Corp. can conduct project activities

Gold-rich Zone 1 within larger copper porphyry system at Northwest Expo identified after intersection of 84.8m grading 1.2g/t Au Eq.

Area covering more than 480 meters strike by 360 meters dip is targeted for resource definition, with a preliminary target of 40 - 50 million tonnes of mineralize material

Infill drilling at Hushamu intersected higher grade material in previously under drilled volumes and also intersected mineralization which continued for 200m below the south side of the PEA pit shell

Metallurgical testing program initiated to develop an enhanced flowsheet with a focus on gold recoveries, use of enhanced process technologies and optimization of copper / molybdenum separation; preliminary recoveries from Northwest Expo will also be determined

Northisle conducted preliminary baseline work including meteorology and hydrological testing and wildlife monitoring in key areas

Surface geophysical program at Pemberton Hills, Northwest Expo, Red Dog, Goodspeed, commenced which will assist with drill target definition for 2023

Continued identification of new or expanded targets with South Hep (between Hushamu and Red Dog) and Downward Dog (NW of Red Dog) being identified for future exploration work

CEO STATEMENT

Sam Lee, President & CEO, stated 'I'm pleased by the progress that Northisle has made during 2022. We have progressed our project on multiple levels by identifying a higher-grade gold zone within the larger porphyry system at Northwest Expo, extending the higher-grade envelope within and below the south side of our current pit shell at Hushamu, completing surface and mapping work on Pemberton Hills which will be used to target an initial drill program, and identifying additional near surface targets within trucking distance from our contemplated processing facilities. Pre-feasibility work is progressing as we commenced in-fill drilling at Hushamu and initiated detailed metallurgical test work. Our recently announced agreement with Quatsino First Nation is a critical step towards building a trusted partnership and essential in any development decision moving forward.

We have strengthened our team and governance practices, adding the skills and diverse perspectives that are essential to progressing our project rapidly and sustainably. I am grateful for the vision, commitment and tenacity of our team throughout the year as we look to redefine how critical resources are responsibly harvested, for the betterment of our people and planet. We are starting to be recognized by rightsholders, stakeholders and peers for this approach and believe that is what sets our project apart from the rest.

We continue to build support in the capital markets having raised another $7 million in 2022, financing one of our boldest exploration programs in the Company's history. We received strong support from new and existing shareholders and continued to increase our institutional shareholder breadth as part of the offering. We were one of the first companies to take advantage of the new critical metals flow through tax credit, thereby minimizing dilution for our existing shareholders. This is but one of a number of initiatives that the Government of Canada has implemented as part of its Critical Minerals Strategy* in which copper is identified as one of the six metals prioritized. We are currently in discussion with various levels of government to identify areas to further accelerate the advancement of our project.

As we look forward to the coming year, we will take advantage of this 'generational opportunity' for critical minerals, and specifically for copper, as we execute on our plan to advance and enhance one of the most developable copper projects in Canada. This is our distinct advantage in a world where much more responsibly sourced copper is needed in a short period of time to address the low carbon future that our planet needs.'

UPCOMING CATALYSTS

Looking forward, Northisle anticipates several catalysts which may be of interest to investors:

Results from Fall 2022 surface exploration program including geophysics, mapping and sampling

Advancement of Pemberton Hills thesis

Northwest Expo resource definition drilling targeting gold-enriched Zone 1

Metallurgical testing results including Hushamu and Northwest Expo

Inaugural Northwest Expo Zone 1 resource estimate (targeting 40-50 million tonnes)

Continued progress on relationships with indigenous rightsholders and local stakeholders

UPCOMING INVESTOR RELATIONS EVENTS

The first quarter of 2023 will be an active one for Northisle with presentations and 1x1s scheduled at multiple conferences in Canada and the USA, including:

January 23-26: AME Round Up, Vancouver

January 25-27: TD Conference, Toronto

January 29-30: VRIC, Vancouver

February 10-12: Capital Events Management, Whistler

February 23-24: Mines & Money, Miami

March 5-8: PDAC, Toronto

March 30-31: 121 Events, Las Vegas

QUALIFIED PERSON

Robin Tolbert, P.Geo., Vice President Exploration of Northisle and a Qualified Person as defined by National Instrument 43-101 - Standards of Disclosure for Mineral Projects, has approved the scientific and technical disclosure contained in this news release.

ABOUT NORTHISLE

Northisle Copper and Gold Inc. is a Vancouver-based company whose mission is to become Canada's leading sustainable mineral resource company for the future. Northisle, through its 100% owned subsidiary North Island Mining Corp., owns the North Island Project, which is one of the most promising copper and gold porphyry projects in Canada. The North Island Project is located near Port Hardy, British Columbia on a more than 34,000-hectare block of mineral titles 100% owned by Northisle stretching 50 kilometres northwest from the now closed Island Copper Mine operated by BHP Billiton. Northisle completed an updated preliminary economic assessment for the North Island Project in 2021 and is now focused on advancement of the project through a prefeasibility study while continuing exploration within this highly prospective land package.

Contact:

On behalf of Northisle Copper and Gold Inc.

Nicholas Van Dyk, CFA

Chief Financial Officer

Tel: (604) 638-2515

Email: info@northisle.ca

WEB: www.northisle.ca

Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this news release.

This news release contains forward-looking statements. These forward-looking statements are based upon the reasonable beliefs of Northisle and its management as of the date of this news release; however, forward-looking statements involve risks and uncertainties and are based upon factors that may change and assumptions that may prove, with the passage of time, to be incorrect as a result of exploration and other risk factors associated with mineral exploration and development that are beyond the control of Northisle. Accordingly, undue reliance should not be placed upon such statements. If factors materially change or assumptions are materially incorrect, the actual results, performance or achievements of Northisle may be materially different from any future results, performances or achievements expressed or implied by such forward-looking statements. Northisle does not undertake any obligation to update or revise any forward-looking statements to reflect new information, future events or otherwise, except as required by applicable law.

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