On March 16, 2012, James J. Mauzey notified the Board of Directors of POZEN Inc. of his intention not to stand for reelection as a Class III Director at the 2012 Annual Meeting of Stockholders of the company to be held on June 7, 2012 and to retire as Chairman of the Compensation Committee and a member of the Nominating/Corporate Governance Committee of the Board at the expiration of his current term. Mr. Mauzey has informed the company that he has no disagreement with the company on any matter relating to the company's operations, policies or practices. On March 21, 2012, Angela M. Larson notified the Board of the company of her intention not to stand for reelection as a Class III Director at the 2012 Annual Meeting of Stockholders of the company to be held on June7, 2012 and to resign a member of the Audit Committee of the Board at the expiration of her current term. Ms. Larson has informed the company that she has no disagreement with the company on any matter relating to the company's operations, policies or practices.