Results show a single, 5-minute treatment of nasal photodisinfection significantly reduces Staphylococcus aureus, a major cause of surgical site infections, in pre-surgical patients
- Top line results met primary endpoint and showed nasal photodisinfection eliminated or significantly decreased Staphylococcus aureus (S. aureus) in 92% of carriers treated per protocol (P<0.001).
- All of the 319 subjects received a single, 5-minute nasal photodisinfection treatment.
- S. aureus is the primary pathogen associated with surgical site infections (SSIs).[i]
- No reportable adverse events
The single-centre, BENEFIT-APDT open-label study was carried out at HCA Healthcare's
"We are pleased that the statistically significant results from the BENEFIT-APDT trial demonstrate the positive therapeutic effect of nasal photodisinfection," said
Lowering surgical site infection rates has been an elusive target for hospitals for many years. Up to 30% of the general population is nasally colonized with S. aureus,[ii] significantly increasing the risk of surgery-related infections. SSIs are the leading cause of readmissions to hospital following surgery, and approximately 3% of patients who contract an SSI die as a consequence of these infections.[iii] Post-operative infections occur in up to 300,000 patients per year in
Ondine expects the full results of the Phase 2 trial to be available in
About
[i] Klevens RM, Edwards JR, Richards CL, et al. Estimating healthcare associated infections and deaths in US hospitals, 2002. Public Health Rep 2007; 122:160e166.
[ii] Hidron AI, Edwards JR, Patel J, Horan TC, Sievert DM, Pollock DA, et al. NHSN annual update: antimicrobial-resistant pathogens associated with healthcare- associated infections: annual summary of data reported to the National Healthcare Safety Network at the
[iii] "Surgical Site Infections. PSNet Patient Safety Network, AHRQ. 2019.
[iv] "Surgical site infections are the most common and costly of hospital infections." ScienceDaily. 2017.
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