3/14/24, 4:42 PM

Ownership Submission

FORM 4

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b). Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

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OMB Number:

3235-0287

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UNITED STATES SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the

Investment Company Act of 1940

(Print or Type Responses)

1. Name and Address of Reporting Person *

2. Issuer Name and Ticker or Trading Symbol

5. Relationship of Reporting Person(s) to Issuer

Phillip Frost, M.D., ET AL

OPKO Health, Inc. [ OPK ]

(Check all applicable)

__ X __ Director

__ X __ 10% Owner

(Last)

(First)

(Middle)

3. Date of Earliest Transaction (Month/Day/Year)

__ X __ Officer (give title below)

_____ Other (specify below)

OPKO Health, Inc.

03/14/2024

CEO & Chairman

4400 Biscayne Blvd.

(Street)

4. If Amendment, Date Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

Miami, FL

33137

___ Form filed by One Reporting Person

_ X _ Form filed by More than One Reporting Person

(City)

(State)

(Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security

2. Transaction

2A. Deemed

3. Transaction

4. Securities Acquired (A)

5. Amount of Securities

6.

7. Nature

(Instr. 3)

Date

Execution Date, if

Code

or Disposed of (D)

Beneficially Owned Following

Ownership

of Indirect

(Month/Day/Year)

any

(Instr. 8)

(Instr. 3, 4 and 5)

Reported Transaction(s)

Form:

Beneficial

(Month/Day/Year)

(Instr. 3 and 4)

Direct (D)

Ownership

(A)

or Indirect

(Instr. 4)

or

(I)

Code

V

Amount

(D)

Price

(Instr. 4)

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3/14/24, 4:42 PMOwnership Submission

Common Stock

03/14/2024

P

500,000

A

$

210,468,225

I

See

0.8886

Footnote

(1)

(2)

Common Stock

3,068,951

D

Common Stock

30,127,177

I

See

Footnote

(3)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned

( e.g. , puts, calls, warrants, options, convertible securities)

1. Title of

2.

3. Transaction

3A. Deemed

4.

5. Number

6. Date Exercisable

7. Title and

8. Price of

9. Number of

10.

11. Nature

Derivative

Conversion

Date

Execution Date, if

Transaction

of

and Expiration Date

Amount of

Derivative

Derivative

Ownership

of Indirect

Security

or Exercise

(Month/Day/Year)

any

Code

Derivative

(Month/Day/Year)

Underlying

Security

Securities

Form of

Beneficial

(Instr. 3)

Price of

(Month/Day/Year)

(Instr. 8)

Securities

Securities

(Instr. 5)

Beneficially

Derivative

Ownership

Derivative

Acquired

(Instr. 3 and 4)

Owned

Security:

(Instr. 4)

Security

(A) or

Following

Direct (D)

Disposed

Reported

or Indirect

of (D)

Transaction(s)

(I)

(Instr. 3, 4,

(Instr. 4)

(Instr. 4)

and 5)

Amount

Date

Expiration

Title

or

Exercisable

Date

Number

Code

V

(A)

(D)

of Shares

Reporting Owners

Reporting Owner Name / Address

Relationships

Director

10% Owner

Officer

Other

Phillip Frost, M.D., ET AL

OPKO Health, Inc.

X

X

CEO & Chairman

4400 Biscayne Blvd.

Miami, FL 33137

Frost Gamma Investments Trust

OPKO Health, Inc.

X

4400 Biscayne Blvd.

Miami, FL 33137

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3/14/24, 4:42 PM

Ownership Submission

Explanation of Responses:

  1. The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $0.8862 to $0.89, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the "Company"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4.
  2. The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.
  3. These securities are held by Frost Nevada Investments Trust, of which the Reporting Person is the trustee and Frost-Nevada, L.P. is the sole and exclusive beneficiary. The Reporting Person is one of seven limited partners of Frost-Nevada, L.P. and the sole shareholder of Frost-Nevada Corporation, the sole general partner of Frost-Nevada, L.P. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.

Signatures

Phillip Frost, M.D., Individually and as Trustee

03/14/2024

** Signature of Reporting Person

Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

  • If the form is filed by more than one reporting person, see Instruction 4(b)(v).
  • Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.

Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

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3/14/24, 4:32 PM

EX-99

JOINT FILER INFORMATION

Name: Frost Gamma Investments Trust

Address:

4400 Biscayne Blvd.

Miami, FL 33137

Designated Filer: Phillip Frost, M.D.

Issuer Name and Ticker Symbol: OPKO Health, Inc. (OPK)

Date of Earliest Transaction: March 14, 2024

Relationship to Issuer: 10% Owner

FROST GAMMA INVESTMENTS TRUST

By: /s/ Phillip Frost, M.D., as Trustee

Phillip Frost, M.D., Trustee

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Opko Health Inc. published this content on 15 March 2024 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 15 March 2024 14:08:06 UTC.