Plethora Solutions Holdings plc : Holding(s) in Company

1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached: ii

Plethora Solutions Holdings PLC

2 Reason for the notification (please tick the appropriate box or boxes):

An acquisition or disposal of voting rights

An acquisition or disposal of qualifying financial instruments which may result in the acquisition of shares already issued to which voting rights are attached

An acquisition or disposal of instruments with similar economic effect to qualifying financial instruments

An event changing the breakdown of voting rights

Other (please specify):

3. Full name of person(s) subject to the notification obligation: iii

Merlin General Partner III Limited

4. Full name of shareholder(s)

(if different from 3.):iv

The Merlin Biosciences Fund III L.P. and The

Merlin Biosciences Fund III 2007 L.P.

5. Date of the transaction and date on

which the threshold is crossed or reached: v

28 October 2013

6. Date on which issuer notified:

28 October 2013

7. Threshold(s) that is/are crossed or reached: vi, vii

6%

8. Notified details:

A: Voting rights attached to shares viii, ix

Class/type of

shares

if possible using the ISIN CODE

Situation previous

to the triggering transaction

Resulting situation after the triggering transaction

Class/type of

shares

if possible using the ISIN CODE

Number

of

Shares

Number

of Voting Rights

Number

of shares

Number of voting

rights

% of voting rights x

Class/type of

shares

if possible using the ISIN CODE

Number

of

Shares

Number

of Voting Rights

Direct

xi

Direct

xii

Indirect

Direct

Indirect

ORDINARY SHARES GB00B06GL868

22,738,736

22,738,736

20,238,736

20,238,736

5.85%

B: Qualifying Financial Instruments

Resulting situation after the triggering transaction

Type of financial instrument

Expiration date xiii

Exercise/

Conversion Period xiv

Number of voting rights that may be

acquired if the instrument is exercised/ converted.

% of voting rights

C: Financial Instruments with similar economic effect to Qualifying Financial Instruments

xv, xvi

Resulting situation after the triggering transaction

Type of financial

instrument

Exercise

price

Expiration date xvii

Exercise/

Conversion period xviii

Number of voting rights

instrument refers to

% of voting rights xix,

xx

Nominal

Delta

Total (A+B+C)

Number of voting rights

Percentage of voting rights

20,238,736

5.85%

Proxy Voting:

10. Name of the proxy holder:

N/A

11. Number of voting rights proxy holder will cease to hold:

N/A

12. Date on which proxy holder will cease to hold voting rights:

N/A

13. Additional information:

Figures are based on total number of voting rights 346,018,872

14. Contact name:

Shafia Zahoor

15. Contact telephone number:

0207 887 7646