You should read the following discussion and analysis of our financial condition
and results of operations in conjunction with the consolidated financial
statements and notes thereto included elsewhere in this report and with the
audited consolidated financial statements and related notes thereto included as
part of our Annual Report on Form 10-K for the year ended December 31, 2019.
Special note regarding forward-looking statements
This report contains forward-looking statements that involve risks and
uncertainties. Our actual results could differ materially from those discussed
in the forward-looking statements. The statements contained in this report that
are not purely historical are forward-looking statements within the meaning of
Section 27A of the Securities Act of 1933, as amended, and Section 21E of the
Securities Exchange Act of 1934, as amended (the "Exchange Act").
Forward-looking statements are often identified by the use of words such as, but
not limited to, "anticipate," "believe," "can," "continue," "could," "estimate,"
"expect," "intend," "may," "plan," "project," "seek," "should," "strategy,"
"target," "will," "would" and similar expressions or variations intended to
identify forward-looking statements. These statements are based on the beliefs
and assumptions of our management based on information currently available to
management. Such forward-looking statements are subject to risks, uncertainties
and other important factors that could cause actual results and the timing of
certain events to differ materially from future results expressed or implied by
such forward-looking statements. Factors that could cause or contribute to such
differences include, but are not limited to, those identified below and those
discussed in the section titled "Risk Factors" included under Part II, Item 1A
below. Furthermore, such forward-looking statements speak only as of the date of
this report. Except as required by law, we undertake no obligation to update any
forward-looking statements to reflect events or circumstances after the date of
such statements.
OVERVIEW
Portola Pharmaceuticals, Inc. (the "Company" or "Portola" or "we" or "our" or
"us") is a biopharmaceutical company focused on the development and
commercialization of novel therapeutics in the areas of thrombosis, other
hematologic diseases and inflammation for patients who currently have limited or
no approved treatment options. Our headquarters is located in South San
Francisco, California. Our lead product is Andexxa [coagulation factor Xa
(recombinant), inactivated-zhzo] which we are marketing under the brand name of
Ondexxya in Europe. Andexxa is the first and only antidote approved by the U.S.
Food and Drug Administration ("FDA") and the European Commission ("EC") for
patients treated with rivaroxaban or apixaban, when reversal of anticoagulation
is needed due to life-threatening or uncontrolled bleeding. We are conducting
clinical trials with cerdulatinib, an investigational oral, dual spleen tyrosine
kinase ("SYK") and Janus kinase ("JAK") inhibitor to treat hematologic cancers.
Pipeline
                Description              Approved or              Stage          Commercial
                                  Investigational Indication                       rights
                                  Patients treated with        U.S.
             Reversal agent for   rivaroxaban or apixaban,     Approval
Andexxa      certain Factor Xa    when reversal of             European       Worldwide
             (fXa) inhibitors     anticoagulation is needed    Union ("EU")   excluding Japan
                                  due to life-threatening or   Approval
                                  uncontrolled bleeding
                                                                              Worldwide
                                                                              excluding

Cerdulatinib Oral, dual SYK and Relapsed/refractory B- and Phase 2a


  topical
             JAK inhibitor        T-cell malignancies                         formulation in
                                                                              non-oncology
                                                                              indications


Approved Products
Andexxa
Andexxa is approved by the FDA as a reversal agent for patients treated with
rivaroxaban or apixaban, when reversal of anticoagulation is needed due to
life-threatening or uncontrolled bleeding. Andexxa was approved under the FDA's
Accelerated

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Approval pathway based on the change from baseline in anti-Factor Xa activity in
healthy volunteers. Continued approval for this indication is contingent upon
post-marketing study results that verify that clinical benefit is conferred to
patients.
We are conducting a randomized controlled trial of Andexxa (U.S.)/Ondexxya (EU)
against a usual care cohort control arm (known as "ANNEXA-I") to provide
clinical data supporting full approval. ANNEXA-I was initiated in early 2019 and
we anticipate that it will include approximately 440 patients with intracranial
hemorrhage and compare outcomes of patients treated with Andexxa to the usual
care on a 1:1 randomized scheme. We plan to conduct this study globally with our
expected completion date in 2023. We are also conducting the ANNEXA-S study: a
single-arm, open-label clinical trial in approximately
200 patients enrolled from approximately 80 hospitals worldwide. ANNEXA-S will
evaluate the efficacy and safety in patients requiring urgent surgery while
taking apixaban, edoxaban, enoxaparin or rivaroxaban. The primary endpoint of
ANNEXA-S is hemostatic efficacy, as assessed by intraoperative assessment of
hemostasis. The study is expected to be completed in 2022.
In the United States, we initially received approval from the FDA in May 2018 to
market product manufactured under our Gen 1 process using the clinical-scale
process at the facility that produced material for our clinical trials. We
conducted a limited launch in the second half of 2018 through an Early Supply
Program ("ESP") intended to reach hospitals with a large number of patients with
Factor Xa bleeds and that were able to start using Andexxa during the ESP
period. On December 31, 2018, the FDA approved our Gen 2 manufacturing process,
which provides commercial scale volume that we believe is sufficient to support
a global launch. In early January 2019, we began shipping Gen 2 product and
commenced a full-scale commercial launch in the United States.
Andexanet alfa received conditional approval under the brand name Ondexxya by
the EC on April 26, 2019. This conditional approval included several
post-authorization requirements, including specific obligations to submit a
final clinical study report for ANNEXA-I, a final clinical study report for the
ANNEXA-4 study, and an obligation to provide some additional pharmacokinetic
data.
We completed our first sales of Ondexxya in Europe in July 2019 and are
executing a phased launch of Ondexxya in Europe, with an initial focus on
Germany, Austria, Denmark, Finland, Sweden, the Netherlands and the United
Kingdom (together, the "Wave 1 Countries"). We also intend to launch Ondexxya in
other countries yet to be determined and establish an early access program for
Ondexxya through a distribution partner. We launched in the EU using Gen 2
product in July 2019.
Andexxa is administered almost exclusively in the hospital and urgent care
settings and is reimbursed either under Medicare Part A through an applicable
Medicare Severity Diagnosis Related Group ("MS-DRG") payment related to the
patient condition for inpatient use, or separately reimbursed under a C code
through Medicare with respect to outpatient usage covered by Medicare Part B
based on Average Sales Price. In addition, the U.S. Centers for Medicare and
Medicaid Services ("CMS") has supplemented Part A reimbursement with a New
Technology Add-on Payment ("NTAP"), which was first effective in October 2018 at
a maximum of 50% of wholesale acquisition cost ("WAC") for the standard dose,
and increased in October 2019 to a maximum of 65% of WAC. The actual NTAP amount
will vary based on the amount by which the cost of a case exceeds the MS-DRG
payment. The CMS NTAP program was created by Congress to support timely access
to innovative therapies used to treat Medicare beneficiaries in the hospital
inpatient setting. For a new technology to qualify for an add-on payment, it
must meet the NTAP definition of "new," demonstrate a substantial clinical
improvement and meet specific cost thresholds.
In March 2020, we announced a data that demonstrated that Andexxa was associated
with a lower rate of in-hospital and 30-day mortality in patients with
life-threatening Factor Xa inhibitor-related bleeds compared with other
treatment options. This included lower mortality across multiple bleed types
including intracranial hemorrhage ("ICH"), gastrointestinal bleeding and
bleeding due to trauma, when compared to 4-factor prothrombin complex
concentrate ("4F-PCC") therapy, which is approved only for the reversal of
warfarin and has no impact on anti-Factor Xa levels.
In addition, in March 2020, we announced a data that using Andexxa to treat
patients with ICH associated with apixaban or rivaroxaban is projected to
provide a net reduction in costs to an acute care hospital. The analysis
compared a clinical scenario with Andexxa to one without it where patients were
given 4F-PCC. Key findings from this analysis related to the net cost reduction
Andexxa can provide for the treatment of ICH associated with oral Factor Xa
inhibitors include: (1) The total cost per hospitalization, considering NTAP
reimbursement for eligible claims, was lower for patients treated with Andexxa
than it was for patients treated with 4F-PCC; and (2) Andexxa generated
reductions in all cost components - intubation, intensive care unit and surgery
costs - except drug costs, though drug costs were offset by the NTAP
reimbursement.
In April 2020, BMS and Pfizer and us agreed to terminate the Collaboration and
License Agreement among the parties, dated February 1, 2016, for the development
and commercialization of andexanet alfa in Japan. As a result, on April 3, 2020
we received a written notice of termination from BMS and Pfizer and will regain
full Japanese rights for andexanet alfa. Japan represents the third largest
market for Factor Xa inhibitors after the United States and the EU 5 countries.
Portola will have

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exclusive rights to develop and commercialize andexanet alfa in the United
States, Europe, Japan and rest of the world markets. Pursuant to the terms of
the agreement, the termination will be effective on October 2, 2020 and over the
next 180 days we intend to work collaboratively with BMS, Pfizer and Japanese
regulators to transition the andexanet alfa Japanese development and
commercialization program to Portola, and advance the plans for regulatory
filing.
In addition, in April 2020, CMS established a new permanent J-code for Andexxa,
facilitating reimbursement in the hospital outpatient setting. This J-code will
take effect on July 1, 2020 and it is expected to replace the previously issued
temporary C-code.
Bevyxxa
Bevyxxa was the first anticoagulant approved in the United States for hospital
and extended duration prophylaxis of venous thromboembolism ("VTE") in adult
patients hospitalized for an acute medical illness who are at risk for
thromboembolic complications due to moderate or severe restricted mobility and
other risk factors for VTE. Bevyxxa was approved by the FDA in June 2017 and we
commenced the commercial launch in the United States in January 2018.
Following the approval of Andexxa in May 2018, we made the business decision to
focus our resources on the launch of Andexxa and significantly scaled back our
commercial efforts on Bevyxxa. Throughout 2019, we engaged with potential
business collaborators for Bevyxxa, and in the fourth quarter of 2019, we
determined that it was unlikely that we will find a viable partner. Accordingly,
we began to wind down Bevyxxa operations to eliminate future operational and
financial obligations.
Product Candidate
Cerdulatinib
Cerdulatinib is our investigational SYK and JAK inhibitor that uniquely inhibits
two key cell signaling pathways implicated in certain hematologic malignancies
and autoimmune diseases. There is a rationale for inhibiting both SYK (B-cell
receptor pathway) and JAK (cytokine receptors) in B-cell malignancies where both
targets have been shown to promote cancer cell growth and survival. In addition,
pre-clinical data suggest an important role for SYK and JAK in Peripheral T-Cell
Lymphoma ("PTCL") tumor survival.
There is a significant unmet need for the treatment of patients with
relapsed/refractory PTCL. Current approved therapies for relapsed/refractory
PTCL are all given via IV infusion and have limited activity with overall
response rates of approximately 30%. In addition, most of these responses are
partial responses. Based on the unmet need and on the activity to date with
cerdulatinib, we have prioritized development in PTCL. Following our End of
Phase 2 meeting with the FDA in January 2019, the FDA requested additional data
supporting the proposed dose and we submitted the requested data. We have
reached an
agreement with the FDA on the design of a registration study ("CELTIC-1"). In
February 2020, we announced that due to internal restructuring to align
resources to drive Andexxa growth, we decided not to initiate the CELTIC-1 trial
for the SYK/JAK inhibitor cerdulatinib until a partner is identified.
Other early stage programs
We continue to progress certain early discovery activities that align with our
scientific expertise.
Reallocating Resources to Drive Growth

In February 2020, we undertook an organizational realignment to focus our
resources on the maximizing the Andexxa and Ondexxya commercial opportunity,
which included a reduction in headcount in order to conserve resources. These
actions result in a pre-tax charge of approximately $1.9 million in the first
quarter of 2020. Related to this organizational realignment, we do not expect
any further significant restructuring costs to be incurred. See Note 11,
Restructuring, to the Condensed Consolidated Financial Statements for further
discussion
COVID-19 Update

In March 2020, the World Health Organization declared the outbreak of COVID-19
as a pandemic, which continues to be spread throughout the United States and the
world. The impact from the rapidly changing market and economic conditions due

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to the COVID-19 outbreak is uncertain, disrupting the business of our clients,
and will impact our business and consolidated results of operations and could
impact our financial condition in the future. Due to the concerns over the
COVID-19 pandemic, effective March 13, 2020, we suspended face-to-face field
activity and instituted a mandatory work from home policy for all employees,
including those in our South San Francisco and European headquarters.

The broader implications of COVID-19 on our results of operations and overall
financial performance remain uncertain. The COVID-19 pandemic and its adverse
effects have become more prevalent in the locations where we, our customers,
suppliers or third-party business partners conduct business and as a result, we
have begun to experience more pronounced disruptions in our operations. We may
experience constrained supply or curtailed customer demand that could materially
adversely impact our business, results of operations and overall financial
performance in future periods. The effect of the COVID-19 pandemic will not be
fully reflected in our results of operations and overall financial performance
until future periods. See "Risk Factors" section below for further discussion of
the possible impact of the COVID-19 pandemic on our business.
Critical accounting policies and significant judgments and estimates
Our management's discussion and analysis of our financial condition and results
of operations is based on our Consolidated Financial Statements, which have been
prepared in accordance with United States generally accepted accounting
principles, ("U.S. GAAP"). The preparation of these Condensed Consolidated
Financial Statements requires us to make estimates and assumptions that affect
the reported amounts of assets and liabilities and the disclosure of contingent
liabilities at the date of the Condensed Consolidated Financial Statements, as
well as the reported revenue generated and expenses incurred during the
reporting periods. Our estimates are based on our historical experience and on
various other factors that we believe are reasonable under the circumstances,
the results of which form the basis for making judgments about the carrying
value of assets and liabilities that are not readily apparent from other
sources. Actual results may differ from these estimates under different
assumptions or conditions.
There have been no significant or material changes in our critical accounting
policies during the three months ended March 31, 2020, as compared to those
disclosed in "Management's Discussion and Analysis of Financial Condition and
Results of Operations-Critical Accounting Policies and Significant Judgments and
Estimates" in our Annual Report on Form 10-K for the year ended December 31,
2019 filed with the SEC on February 28, 2020.
Recent Accounting Pronouncements
See Note 2, Summary of Significant Accounting Policies, to the Condensed
Consolidated Financial Statements included in Part I, Item 1 of this Quarterly
Report on Form 10-Q for information regarding recent accounting pronouncements.
Results of operations
Comparison of the three months ended March 31, 2020 and 2019
Revenue
                                              Three Months Ended March
                                                        31,
                                                 2020          2019        Change     % Change
                                                     (in thousands, except percentages)
Andexxa                                       $  23,055     $ 20,285     $  2,770       14%
Ondexxya                                          2,582            -        2,582        *
Bevyxxa                                               -           77          (77 )      *
Total product revenue, net                       25,637       20,362        5,275       26%

Total collaboration and license revenue             752        1,807       (1,055 )    (58%)

Total revenues                                $  26,389     $ 22,169     $  4,220       19%


* Percentage not meaningful
The increase in total revenues during the three months ended March 31, 2020
compared to the three months ended March 31, 2019 was primarily attributable to:
•       an increase in net revenue of Andexxa during the first quarter of 2020
        compared to the same period in 2019; and



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• Ondexxya revenue which started from the third quarter of 2019; offset by

• a decrease in Phase 3 collaboration revenue from certain collaboration

partners as related performance obligations had been mostly fulfilled by

the first quarter of 2019.




Cost of Sales
                     Three Months Ended March 31,
                           2020                   2019       Change      % Change
                               (in thousands, except percentages)
Cost of sales $         4,320                   $ 7,150    $ (2,830 )     (40 )%

The decrease in cost of sales during the three months ended March 31, 2020 compared to the three months ended March 31, 2019 is primarily attributable to: • an excess and obsolete inventory charge of $3.7 million recorded in the


        first quarter of 2019 related to Gen 1 transition of Andexxa
        manufacturing process; and

• a decrease in cost of sales for Andexxa Gen 2 inventories in the current

period as compared to mostly Gen 1 inventories costs in the first quarter


        of 2019.



Cost of product sales also consists of certain finishing costs incurred after
FDA approvals related to approved products sold, in addition to certain
distribution and overhead costs. We expect costs of sales to increase in
relation to product revenues as we deplete inventories that we had expensed
prior to receiving FDA approvals.
Research and development expenses
                                                         Three Months Ended March
                                                                   31,
                                            Phase of        2020          2019        Change       % Change
Product candidate                          Development            (in thousands, except percentages)
Andexanet alfa                             Phase 2/3/4   $  15,986     $ 24,890     $ (8,904 )       (36 %)
Betrixaban                                  Phase 1/3        1,195          566          629         111 %
Cerdulatinib                               Phase 1/2a        7,171        7,197          (26 )         -  %
Other research and development expenses(1)                   1,737        2,931       (1,194 )       (41 )%
Total research and development expenses                  $  26,089     $ 

35,584 $ (9,495 ) (27 %)

(1) Amounts in all periods include costs for other potential product candidates.




The net decrease in total research and development expenses during the three
months ended March 31, 2020 compared to the three months ended March 31, 2019
was primarily attributable to:
• a decrease in Andexanet alfa program costs during the first quarter of 2020;


•       a $5.8 million charge for Lonza's first tranche purchase right that was

measured up to the settlement date in the first quarter of 2019; and

• a decrease in program costs related to other potential product candidates.

Selling, general and administrative expenses


                                              Three Months Ended March
                                                        31,
                                                 2020          2019        Change       % Change
                                                       (in thousands,

except percentages) Selling, general and administrative expenses $ 54,418 $ 53,034 $ 1,384

           3 %


The increase in selling, general and administrative expenses during the three
months ended March 31, 2020 compared to the three months ended March 31, 2019
was primarily attributable to:

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• an increase in building rent and insurance of $1.1 million resulting from


        the headquarters office lease renewal in June 2019 and expansion of EU
        operations.

Interest and other (expense) income, net


                                              Three Months Ended March 31,
                                                 2020             2019          Change      % Change
                                                         (in thousands, except percentage)
Interest and other (expense) income, net       (2,186 )             1,984   

$ (4,170 ) (210 )%




The decrease in interest and other (expense) income, net, during the three
months ended March 31, 2020 compared to the three months ended March 31, 2019
was primarily attributable to
•       an increase in net loss on remeasurement from embedded derivatives by

$3.6 million; and

• a decrease in interest income earned from investments.




Interest expense
                        Three Months Ended March 31,
                              2020                   2019      Change     % Change
                                 (in thousands, except percentages)
Interest expense $         8,147                   $ 6,481    $ 1,666        26 %


The increase in interest expense during the three months ended March 31, 2020
compared to the three and three months ended March 31, 2019 was primarily due
to:
•       $62.5 million of funding received in each of March and November 2019
        under the Credit Agreement with HCR and Athyrium.


Liquidity and capital resources
Due to our significant research and development and selling, general and
administrative expenditures, we have generated significant operating losses
since our inception. We have financed our operations primarily through sales of
our equity securities, collaborations, including loans from our collaboration
partners and third parties, a royalty-based financing arrangement, and sales of
commercial and development rights to some of our product candidates. Our
expenditures are related to research and development activities, including
clinical trial and manufacturing-related costs and selling, general and
administrative costs, including commercial preparation, launch and operating
costs. At March 31, 2020, we had cash, cash equivalents and investments of
$394.1 million which includes $50.0 million minimum cash holdings required by
our secured term loan agreement (See Note 7, Long Term Obligations, to the
Condensed Consolidated Financial Statements). Our cash, cash equivalents and
investments are held in a variety of interest-bearing instruments, including
investments backed by U.S. government agencies, corporate debt securities and
money market accounts. Cash in excess of immediate requirements is invested with
a view toward liquidity and capital preservation, and we seek to minimize the
potential effects of concentration and degrees of risk.
We estimate our existing capital resources, together with interest thereon, to
be sufficient to meet our projected operating requirements into the second
quarter of 2021 while maintaining compliance with covenants pursuant to the 2019
Credit Agreement of a minimum of $50.0 million of cash on hand. We have based
this estimate on assumptions that may prove to be wrong, and we could utilize
our available capital resources sooner than we currently expect. In light of the
estimated costs to support the global launch and continued development of
Andexxa, we will need to implement cost saving measures, defer the timing of
capital expenditures and potentially raise additional capital through a
combination of public or private equity offerings, debt financings,
collaborations, strategic alliances, licensing arrangements and/or other
marketing and distribution arrangements. We currently have no credit facility or
committed sources of capital other than potential milestones receivable under
our current collaboration and license agreements. Our future funding
requirements will depend on many factors, including the following:

                                       6


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•            the timing, receipt and amount of sales, profit sharing or
             royalties, if any, from our current and potential products;


•            the cost of manufacturing our current products and product
             candidates, including process improvements in order to manufacture
             product candidates at commercial scale, and establishing commercial
             supplies of our product candidates;


•            the cost and timing of establishing sales, marketing and
             distribution capabilities in the United States and abroad;


•            the terms and timing of any other collaborative, licensing and other
             arrangements that we may establish;

• the receipt of any collaboration payments;

• the number and characteristics of product candidates that we pursue;

• the cost, timing and outcomes of regulatory approvals;




•            the scope, rate of progress, results and cost of our clinical
             studies, preclinical testing and other related activities;


•            the cost of preparing, filing, prosecuting, defending and enforcing
             any patent claims and other intellectual property rights;


•            the extent to which we acquire or invest in businesses, products or
             technologies, although we currently have no commitments or
             agreements relating to any of these types of transactions; and


•            partnerships and other strategic options for our products and
             product candidates.


If we need to raise additional capital to fund our operations, funding may not
be available to us on acceptable terms, or at all. If we are unable to obtain
needed financing, we will need to curtail planned activities to reduce costs.
Doing so will likely have an unfavorable effect on our ability to execute on our
business plan, and have an adverse effect on our business, results of operations
and future prospects. We may seek to raise any necessary additional capital
through a combination of public or private equity offerings, debt financings,
collaborations, strategic alliances, licensing arrangements and other marketing
and distribution arrangements. To the extent that we raise additional capital
through marketing and distribution arrangements or other collaborations,
strategic alliances or licensing arrangements with third parties, we may have to
relinquish valuable rights to our product candidates, future revenue streams,
research programs or product candidates or to grant licenses on terms that may
not be favorable to us. If we do raise additional capital through public or
private equity offerings, the ownership interest of our existing stockholders
will be diluted, and the terms of these securities may include liquidation or
other preferences that adversely affect our stockholders' rights. If we raise
additional capital through debt financing, we may be subject to covenants
limiting or restricting our ability to take specific actions, such as incurring
additional debt, making capital expenditures or declaring dividends.
The following table summarizes our cash flows for the periods indicated:
                                                                Three Months Ended March 31,
                                                                  2020                 2019
                                                                       (in thousands)
Cash used in operating activities                           $      (71,100 )     $      (63,635 )
Cash provided by investing activities                               52,927               82,103
Cash provided by financing activities                                  101               69,840
Effect of exchange rate changes on cash, cash equivalents              (23 )                  -
and restricted cash
Net (decrease) increase in cash, cash equivalents and       $      (18,095 )     $       88,308
restricted cash


Cash used in operating activities
Cash used in operating activities for the three months ended March 31,
2020 reflected a net loss of $68.8 million, offset by a non-cash stock-based
compensation charge of $9.5 million, non-cash interest incurred on the Notes
payable, royalty-based debt and Secured Term Loans of $5.1 million,
remeasurement loss on our embedded derivatives of $3.2 million, a provision for
excess and obsolete inventories charge of $2.1 million, and amortization on the
lease right-of-use assets of $1.2 million. Cash used in operating activities
also reflected a $15.6 million decrease due to an increase in inventories as we
build out commercial inventory supplies, a $6.1 million increase due to a
decrease in trade and other receivables, net from our Andexxa and

                                       7

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Ondexxya customers, a $3.7 million decrease due to royalty payments made to BMS,
Pfizer and HCR, and a $10.2 million decrease due to a decrease in accrued and
other liabilities.
Cash used in operating activities for the three months ended March 31, 2019
reflected a net loss of $78.1 million, offset by a non-cash stock-based
compensation charge of $17.9 million, non-cash interest incurred on the Notes
payable and royalty-based debt of $6.5 million, and a provision for excess and
obsolete inventories charge of $3.9 million. Cash used in operating activities
also reflected a $1.5 million increase due to a decrease in inventories as we
use commercial inventory supplies, a $5.9 million decrease due to an increase in
trade and other receivables, net from our Andexxa customers, a $2.0 million
decrease due to royalty payments made to BMS, Pfizer and HCR, and a $4.5 million
decrease due to a decrease in accounts payable.
Cash provided by investing activities
Cash provided by investing activities for the three months ended March 31,
2020 was primarily related to proceeds from maturities of investments of $100.4
million, partially offset by investment purchases of $46.5 million and fixed
asset purchases of $1.0 million.
Cash provided by investing activities for the three months ended March 31, 2019
was primarily related to proceeds from maturities of investments of $124.1
million, partially offset by investment purchases of $41.7 million and fixed
asset purchases of $0.4 million.
Cash provided by financing activities
Cash provided by financing activities for the three months ended March 31,
2020 was primarily related to net proceeds from the issuance of common stock
pursuant to equity awards of $0.4 million, offset by payments of long-term
obligation to a collaborator of $0.3 million.
Cash provided by financing activities for the three months ended March 31, 2019,
was primarily related to net proceeds from debt issuance of $59.2 million and
net proceeds from the issuance of common stock pursuant to equity awards of
$10.1 million.
Off-balance sheet arrangements and contractual obligations
We lease our corporate headquarters, laboratory and other U.S. facilities under
an operating lease expiring in March 2023. These leases require us to pay taxes,
insurance, maintenance and minimum lease payments.
There were no material changes during the three months ended March 31, 2020
outside of the ordinary course of business and in our specified contractual
obligations as disclosed in our Annual Report on Form 10-K for the year ended
December 31, 2019 filed with the SEC on February 28, 2020.

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