The poster, entitled, 'Blocking Tumor Support from Cancer Associated Fibroblasts in Tumor Microenvironment,' describes a novel therapeutic strategy to decrease tumor microenvironment (TME) influence in drug uptake, immune evasion, tumor progression and further tumor dispersion. A copy of the publication can be accessed from the Company's website, via the following link: https://www.propanc.com/news-media/publications.
Despite cancer research budgets continuing to grow, and even with knowledge of the complex interaction between a tumor and its host organism, standard treatments are still inefficient, which continues to lead to extremely serious side effects and to the development of tumor relapses due to acquired chemoresistance. Cancer Associated Fibroblasts (CAFs), as the main cell population of the TME, play a key role in all stages of tumorigenesis, from tumor initiation to the induction of the pre-metastatic niche settlement; thus, it appears to seem evident that novel therapeutic approaches should hamper CAFs support to tumor cells.
In addition to the serious side effects from standard treatment, which we all acknowledge, the biggest question facing cancer sufferers is whether the cancer will return, post-treatment. This recurrence often results from acquired chemoresistance as a result of the influence toward the tumor microenvironment from CAFs,' said Dr.
PRP is a mixture of two proenzymes, trypsinogen and chymotrypsinogen from bovine pancreas, administered by intravenous injection. A synergistic ratio of 1:6 inhibits growth of most tumor cells. Examples include kidney, ovarian, breast, brain, prostate, colorectal, lung, liver, uterine, and skin cancers.
About
The Company's novel proenzyme therapy is based on the science that enzymes stimulate biological reactions in the body, especially enzymes secreted by the pancreas. These pancreatic enzymes could represent the body's primary defense against cancer.
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