Item 1.01 Entry into a Material Definitive Agreement.

Adoption of Agreement and Plan of Merger and Consummation of Reorganization

Inspyr Therapeutics, Inc,. a Delaware corporation ("Inspyr"), is implementing a holding company reorganization pursuant to an Agreement and Plan of Merger (the "Merger Agreement"), dated as of September 28, 2021, among Inspyr, Rebus Holdings, Inc. a Delaware corporation ("Holding Company"), and Rebus Sub, Inc., a Delaware corporation and wholly-owned subsidiary of Holding Company ("Merger Sub"), which will result in the Holding Company becoming the direct parent company of Inspyr and replacing Inspyr as the public company trading on the OTC Markets ("OTC") (the "Reorganization").

Pursuant to the Merger Agreement, Merger Sub will merge with Inspyr pursuant to the filing of a certificate of merger (the "Certificate of Merger"), with Inspyr surviving as a direct, wholly-owned subsidiary of Holding Company (the "Merger"). At the effective time of the Merger (the "Effective Time"), subject to the approval of the Financial Industry Regulatory Authority or FINRA:

(i) Each outstanding share of Inspyr common stock, par value $0.0001 per share


     ("Inspyr Common Stock"), will automatically be converted into one share of
     common stock, par value $0.0001 per share, of Holding Company ("Holding
     Company Common Stock"), having the same designation, rights, powers, and
     preferences, and qualifications, limitations, and restrictions as a share of
     Inspyr Common Stock immediately prior to the Reorganization;



(ii) Each outstanding share of Inspyr Series A Convertible Preferred Stock, par


      value $0.0001 per share ("Inspyr Series A Stock"), will automatically be
      converted into one share of Series A Convertible Preferred Stock par value
      $0.0001 per share, of Holding Company ("Holding Company Series A Stock"),
      having the same designation, rights, powers, and preferences, and
      qualifications, limitations, and restrictions as a share of Inspyr Series A
      Stock immediately prior to the Reorganization;



(iii) Each outstanding share of Inspyr Series B Convertible Preferred Stock, par


       value $0.0001 per share ("Inspyr Series B Stock"), will automatically be
       converted into one share of Series B Convertible Preferred Stock par value
       $0.0001 per share, of Holding Company ("Holding Company Series B Stock"),
       having the same designation, rights, powers, and preferences, and
       qualifications, limitations, and restrictions as a share of Inspyr Series B
       Stock immediately prior to the Reorganization;



(iv) Each outstanding share of Inspyr Series C Convertible Preferred Stock, par


      value $0.0001 per share ("Inspyr Series C Stock"), will automatically be
      converted into one share of Series C Convertible Preferred Stock par value
      $0.0001 per share, of Holding Company ("Holding Company Series C Stock"),
      having the same designation, rights, powers, and preferences, and
      qualifications, limitations, and restrictions as a share of Inspyr Series C
      Stock immediately prior to the Reorganization;



(v) Each outstanding share of Inspyr Series D Convertible Preferred Stock, par


     value $0.0001 per share ("Inspyr Series D Stock"), will automatically be
     converted into one share of Series D Convertible Preferred Stock par value
     $0.0001 per share, of Holding Company ("Holding Company Series D Stock"),
     having the same designation, rights, powers, and preferences, and
     qualifications, limitations, and restrictions as a share of Inspyr Series D
     Stock immediately prior to the Reorganization;



(vi) Each outstanding share of Inspyr Series E Convertible Preferred Stock, par


      value $0.0001 per share ("Inspyr Series E Stock"), will automatically be
      converted into one share of Series E Convertible Preferred Stock par value
      $0.0001 per share, of Holding Company ("Holding Company Series E Stock"),
      having the same designation, rights, powers, and preferences, and
      qualifications, limitations, and restrictions as a share of Inspyr Series E
      Stock immediately prior to the Reorganization; and



(vii) Each outstanding share of Inspyr Series F Convertible Preferred Stock, par


       value $0.0001 per share ("Inspyr Series F Stock"), will automatically be
       converted into one share of Series F Convertible Preferred Stock par value
       $0.0001 per share, of Holding Company ("Holding Company Series F Stock"),
       having the same designation, rights, powers, and preferences, and
       qualifications, limitations, and restrictions as a share of Inspyr Series F
       Stock immediately prior to the Reorganization.



Accordingly, upon consummation of the Reorganization (and the Reverse Stock Split as defined below), Inspyr stockholders will automatically became stockholders of Holding Company, on a one-for-one basis, with the same number and approximate ownership percentage of shares of the same class as they held in Inspyr immediately prior to the Effective Time. The Reorganization is intended to be a tax-free transaction for U.S. federal income tax purposes for Inspyr stockholders.





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The Reorganization is being conducted pursuant to Section 251(g) of the General Corporation Law of the State of Delaware (the "DGCL"), which provides for the formation of a holding company without a vote of the stockholders of the constituent corporation. The conversion of stock will occur automatically without an exchange of stock certificates. In addition, at the Effective Time:

? Each outstanding and unexpired option to purchase Inspyr Common Stock will

automatically be converted into one share of Holding Company Common Stock; . . .

Item 3.03 Material Modification of Rights of Security Holders.

At the Effective Time of the Merger, each share of capital stock of Inspyr issued and outstanding immediately prior to the Effective Time will automatically convert into a share of the same class or series designation of the Holding Company, having the same designations, rights, powers, and preferences and the qualifications, limitations, and restrictions as such applicable share of Inspyr capital stock immediately prior to the Effective Time.

The information set forth in Item 1.01 under the heading "Adoption of Agreement and Plan of Merger and Consummation of Reorganization" and in Item 5.03 is hereby incorporated by reference in this Item 3.03.

Item 5.02 Departure of Directors or Certain Officers; Election of Directors;


          Appointment of Certain Officers; Compensatory Arrangements of Certain
          Officers.



The information set forth in Item 1.01 under the heading "Post Reverse Stock Split and Reorganization Information" is hereby incorporated by reference in this Item 5.02.

Item 5.03 Amendments to Articles of Incorporation or Bylaws; Change in Fiscal


          Year.



As described in Item 1.01 above under the heading "Reverse Stock Split", Inspyr filed the Amended and Restated Certificate of Incorporation effecting the Reverse Stock Split.

Upon consummation of the Reorganization, the Amended and Restated Certificate of Incorporation of Inspyr will be amended and restated through the Certificate of Merger to (i) decrease the authorized number of shares of Inspyr Common Stock from one billion thirty million (1,030,000,000) shares to one thousand (1,000) shares; (ii) remove the authorized number of shares of Preferred Stock; (iii) add a provision, which is required by Section 251(g) of the DGCL, that provides that any act or transaction by or involving Inspyr, other than the election or removal of directors, that requires for its adoption under the DGCL or the Amended and Restated Certificate of Incorporation, the approval of the stockholders of Inspyr shall require the approval of the stockholders of the Holding Company by the same vote as is required by the DGCL and/or the Amended and Restated Certificate of Incorporation; and (iv) add and remove provisions as appropriate for a wholly-owned subsidiary.

In addition, the Amended and Restated Bylaws of Inspyr, dated January 6, 2010, were amended and restated (as amended and restated, the "Inspyr Bylaws") to add and remove provisions as appropriate for a wholly-owned subsidiary.

The foregoing descriptions of the (i) Amended and Restated Certificate of Incorporation, (ii) amendment to the Amended and Restated Certificate of Incorporation as contained in the Certificate of Merger, and (iii) Inspyr Bylaws do not purport to be complete and are qualified in their entirety by reference to the Certificate of Merger and the Bylaws, copies of which are filed as Exhibit 3.01(i), Exhibit 3.02(i), and Exhibit 3.03(ii) respectively, to this Current Report on Form 8-K and incorporated by reference herein.





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Forward-Looking Statements.


This Current Report on Form 8-K contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 of and Section 21E of the Exchange Act. Forward-looking statements can be identified by words such as "anticipates," "intends," "plans," "seeks," "believes," "continues," "could," "estimates," "expects," "guidance," "may," "might," "outlook," "possibly," "potential," "projects," "prospects," "should," "will," "would," and similar references to future periods, but the absence of these words does not mean that a statement is not forward-looking. These statements include risks inherent in the development and commercialization of potential products, uncertainty of clinical trial results or regulatory approvals or clearances, need for future capital, dependence upon collaborators and maintenance of our intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements. While forward-looking statements are based on assumptions and analyses made by us that we believe to be reasonable under the circumstances, whether actual results and developments will meet our expectations and predictions depend on a number of risks and uncertainties which could cause our actual results, performance, and financial condition to differ materially from our expectations. See "Risk Factors" in our Annual Report on Form 10-K for the fiscal year ended December 31, 2020 and in our quarterly reports on Form 10-Q filed with the Commission for a discussion of risk factors that affect our business. Any forward-looking statement made by Inspyr in this Current Report on Form 8-K speaks only as of the date on which it is made. Factors or events that could cause our actual results to differ may emerge from time to time, and it is not possible for us to predict all of them. Inspyr undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future development, or otherwise, except as may be required by law.

Item 9.01 Financial Statement and Exhibits.






Exhibit
No.                                          Description
  2.01           Form of Agreement and Plan of Merger among Inspyr Therapeutics, Inc.,
               Rebus Holdings, Inc., and Rebus Sub, Inc.
  3.01(i)        Amended and Restated Certificate of Incorporation of Inspyr
               Therapeutics, Inc. effecting 1-for-75 Reverse Stock Split.
  3.02(i)        Certificate of Merger between Inspyr Therapeutics, Inc. and Rebus Sub,
               Inc.
  3.03(ii)       Amended and Restated Bylaws of Inspyr Therapeutics, Inc.




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