Regulus Therapeutics Inc. announced the nomination of RGLS5579 as a clinical candidate for the treatment of glioblastoma multiforme. As recently disclosed at a scientific meeting, a single dose of RGLS5579 demonstrated increased survival as monotherapy vs. control in an orthotopic GBM animal model (18% increase in median survival vs. control) and in combination with temozolomide, a single dose of RGLS5579 significantly increased median survival (159% increased median survival vs. control; p = 0.0001). Standard of care temozolomide as a single agent increased median survival by 27% vs. control, therefore the combination of RGLS5579 plus temozolomide demonstrated synergistic efficacy in this model. RGLS5579 has completed the clinical candidate screening process demonstrating appropriate preliminary safety and drug-like properties.