Skin barrier function has been implicated as a driving factor in many dermatological disorders, including Atopic Dermatitis (AD). AD is one of the most prevalent disorders in the world, affecting up to 20% of children globally. Additionally, skin barrier function is commonly assessed in the research and development of pharmaceutics and cosmetic products.
The study was performed on healthy adults between 22 and 65 years of age and aimed at determining factors that influence the measurement results of both EIS and TEWL. The top-line results of the study indicated that:
- TEWL measurements were influenced by physical activity, body cream application, skin washing, and caffeine intake.
- EIS measurements were only influenced by body cream application and skin washing.
- EIS was not influenced by physical activity or caffeine intake.
- Both the abdomen and the volar forearm were identified as useful anatomical locations for EIS measurements.
The authors concluded that EIS (Nevisense) can assess skin barrier function with less sensitivity to confounding lifestyle factors than TEWL.
"For
The full results of the study have now been published in the scientific journal Annals of Dermatology and can be found here: https://anndermatol.org/DOIx.php?id=10.5021/ad.23.052
The study was carried out at
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