On March 21, 2018, the Board of Directors of The Medicines Company appointed Christopher Visioli the Chief Financial Officer and Treasurer of the Company, effective immediately. Mr. Visioli replaced William B. O'Connor, who is retiring from the Company. Mr. O'Connor ceased serving as the Company's Chief Financial Officer on March 21, 2018, but will remain with the Company as a special advisor to the Chief Executive Officer through 2018 and will be primarily focused on the close-out of the Company's non-core businesses and products.

Mr. Visioli previously served as Senior Vice President, Financial Strategy for the Company from January 2015 to March 2018 and Vice President, Cardiovascular Care from January 2013 to December 2014.