GeNeuro : Signs CRADA Agreement with NIH to Develop Novel Antibody Treatment for ALS

Press release

• Partnership focuses on antibodies targeting HERV-K, a potential ALS causal factor

Under the terms of the agreement, GeNeuro will provide antibodies designed to block the activity of HERV-K envelope protein. These candidate antibodies will be tested in cellular and animal models of HERV-K associated ALS by the NINDS with the aim to achieve preclinical proof-of-concept of this novel therapeutic avenue addressing ALS pathogenesis.

"This agreement truly combines the strengths of both parties; the pioneering work done by GeNeuro in the HERV field, especially in the development of antibodies able to neutralize HERV encoded proteins in associated diseases, and the excellent NIH research on the involvement of HERV-K in sporadic ALS led by Dr. Avindra Nath and his group," said Hervé Perron, Chief Scientific Officer at GeNeuro. "With this partnership, we aim to show that blocking this pathogenic HERV protein could lead to a novel ALS treatment and, in time, expand the GeNeuro clinical pipeline into additional neurological disorders."

Dr. Nath and his research group recently discovered the targeted expression and the pathogenic effects of the envelope protein from HERV-K in ALS1. Furthermore, the NIH team has developed cellular and transgenic mouse models that can be used to evaluate the anti-HERV-K antibodies as therapeutics candidates to treat ALS.

"We are excited about this collaboration as an initial step towards developing a therapeutic approach for altering the course of the disease for patients with ALS," said Dr. Nath, clinical director at the National Institute of Neurological Disorders and Stroke (NINDS).

About ALS

Amyotrophic lateral sclerosis (ALS), commonly referred to as Lou Gehrig's disease or clinically as motor neuron disease, is a fatal, rapidly progressive neurodegenerative disease characterized by loss of motor neurons. The incidence of ALS is approximately 1-3 per 100,000 individuals, and is consistent across diverse populations.

1 Science Translational Medicine (30 Sep 2015) "Human endogenous retrovirus-K contributes to motor neuron disease"

About GeNeuro

GeNeuro's mission is to develop safe and effective treatments against neurological disorders and autoimmune diseases, such as multiple sclerosis, by neutralizing causal factors encoded by HERVs, which represent 8% of human DNA.

GeNeuro is based in Geneva, Switzerland and has R&D facilities in France at sites in Archamps, Haute-Savoie and in Lyon. It has 30 employees and rights to 16 patent families protecting its technology.

For more information, visit: www.geneuro.com

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