By a News Reporter-Staff News Editor at Pharma Business Week -- Fresh data on Drugs and Therapies - Central Nervous System Agents are presented in a new report. According to news originating from Maharashtra, India, by NewsRx correspondents, research stated, "A novel process for the synthesis of tetrabenazine (1) and deutetrabenazine (2), two well-known drugs used for the treatment of chorea associated with Huntington's disease, has been developed."
Our news journalists obtained a quote from the research from Lupin, Ltd., "All of the reaction parameters were optimized through a series of reactions and by using Design of Experiment techniques. The newly developed methods are industrially scalable and employ cheap, commercially available raw materials and hence are highly efficient."
According to the news editors, the research concluded: "The added advantage is that the developed processes evade the use of genotoxic alkylating agents and therefore could be considered as safe and viable alternatives to the existing methods."
For more information on this research see: Novel Process for Preparation of Tetrabenazine and Deutetrabenazine. Organic Process Research & Development, 2018;22(4):520-526. Organic Process Research & Development can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Organic Process Research & Development - www.pubs.acs.org/journal/oprdfk)
The news correspondents report that additional information may be obtained from P.C. Ray, Lupin Ltd., Lupin Res Pk, Pune 412115, Maharashtra, India. Additional authors for this research include Y.D. Pawar, D.T. Singare, T.N. Deshpande and G.P. Singh (see also Drugs and Therapies - Central Nervous System Agents).
The direct object identifier (DOI) for that additional information is: https://doi.org/10.1021/acs.oprd.8b00011. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.
Keywords for this news article include: Maharashtra, India, Asia, Central Nervous System Agents, Health and Medicine, Drugs and Therapies, Tetrabenazine, Lupin Ltd., Business, Lupin, Ltd.
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2018, NewsRx LLC