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* Wizz Air jumps on upbeat annual outlook

* Crest Nicholson down, flags slowdown worries

* FTSE 100 down 0.1%, FTSE 250 adds 0.1%

June 8 (Reuters) - UK's main stock index edged lower on Thursday, dragged by a slump in shares of mobile operator Vodafone, while investors assessed the scope for continued interest rate hikes and their impact on the British economy.

The resource-heavy FTSE 100 was down 0.1% as of 0835 GMT, while the domestically-focused FTSE 250 midcap index edged 0.1% higher.

A surprise rate hike by the Bank of Canada spooked investors globally, sparking fears that major global central banks could stick to their rate tightening cycles for longer.

"Over here, the BoE (Bank of England) is already expected to hike rates again this month given the strong CPI numbers ... if anything, it has simply reinforced those expectations" said Stuart Cole, chief macro economist at Equiti Capital.

"But it has caused the wider market to reassess its thinking on how close we were to the end of the current rate hiking cycle."

Investors now await data on UK's labour market, economic growth and monthly industrial and manufacturing output next week to gauge the state of the economy and the policy tightening path.

While precious metals and chemicals were the worst hit sector indexes, automobiles and construction and materials were the top gainers.

Vodafone Group plc fell 4.4%, set for its steepest one-day drop in three weeks, retreating from a one-week high hit on Wednesday on a Reuters report that the company and Hutchison are in the final stages of a merger agreement for their British operations.

Wizz Air Holdings plc gained 2.6% after the European low-cost airline forecast a net profit of 350 million euros to 450 million euros ($374.57 million to $481.59 million) in its current financial year.

Crest Nicholson Holdings plc dropped 5.8% after warning of further slowdown in the British housing market.

($1 = 0.9344 euros) (Reporting by Ankika Biswas in Bengaluru; Editing by Rashmi Aich and Sonia Cheema)