The board (the "Board") of directors (the "Directors") of 3SBio Inc. (the "Company") announced that with effect from 30 December 2022, Mr. Tang Ke ("Mr. Tang") has resigned as a non-executive Director and a member of the remuneration committee (the "Remuneration Committee") of the Company. The Board further announces that with effect from 30 December 2022, Dr. Zhang Dan () "Dr. Zhang") has been appointed as an independent non-executive Director. Dr. Zhang Dan, aged 59, has extensive experience in the field of medicine and pharmaceuticals, and has held numerous respectable and prestigious positions in the industry.

Dr. Zhang served as the first chairman of the board of directors (Greater China region) and the Vice- President of the US company, Quintiles Transnational Corp. Dr. Zhang had experience working at Sigma Tauresearch Inc., a company established in Italy, during which he was in charge of the clinical development and safety evaluations of drugs in respect of the market in North America. In 2007, Dr. Zhang co-founded ClinChoice Inc. (formerly known as FMD China, a clinical contract research organization (CRO) dedicated to the development of innovative medicines.

He was the chairman of this company from 2007 to 2019, and has been the Chief Strategy Officer and a director of this company since 2020. He has also served as (i) the Chief Scientist at Shenzhen Grandbaybio Development Consulting Co. Limited since 2020; (ii) the co-chairman of the board of directors of Hong Ji Biotechnology (Beijing) Co.

Limited since 2021; and (iii) the co-chairman of the board of directors of Jiangsu Hillgene Medical Co. Limited since 2022. Dr. Zhang served as a consultant and a visiting professor at Peking Union Medical College and Harbin Medical University, respectively.

Dr. Zhang has been a board member of China Pharmaceutical Innovation and Research Development Association (PhIRDA) from 2020 to 2022. He currently also serves as the head of the ICH E19 IFPMA expert committee and a ICH working group expert in the National Medical Products Administration (NMPA). Dr. Zhang completed his pre-medical training at the Department of Biology at Peking University in 1984.

He then studied Medicine at Peking Union Medical College from 1981 to 1989, and was subsequently awarded with a Doctor of Medicine by the State Council of the PRC government. He further obtained a Master of Public Health degree from Harvard University in 1990 and a Master of Science in Health Care Management degree in 1995 from the Wharton School of the University of Pennsylvania. He was also elected as a foreign member of the Russian Academy of Engineering in 2020.

Dr. Zhang has entered into a letter of appointment with the Company in respect of the appointment as an independent non-executive Director for a term of one year commencing from 30 December 2022. Pursuant to the letter of appointment, Dr. Zhang is entitled to a director's fee of HKD 300,000 per annum, which was determined by the Board on the recommendation of the Remuneration Committee, having considered Dr. Zhang's expected contribution to the Company in terms of time, effort and his expertise, and with reference to the level of remuneration of the other independent non-executive Directors. Pursuant to the second amended and restated articles of association of the Company, Dr. Zhang shall hold office until the next following annual general meeting of the Company following his appointment and shall then be eligible for re-election at the meeting and thereafter, shall be subject to retirement by rotation at the annual general meetings of the Company at least once every three years.

In light of the above resignation of non-executive Director and appointment of independent non-executive Director, with effect from 30 December 2022, Dr. Zhang has been appointed as a member of the Remuneration Committee.