Achillion Pharmaceuticals, Inc. announced achievement of enrollment in their ACH-4471 Phase 2 paroxysmal nocturnal hemoglobinuria (PNH) trial in combination with eculizumab. In the Phase 2 trial, patients with an inadequate response to eculizumab as monotherapy are being evaluated for increases in hemoglobin and reduced transfusions over 24-weeks. Early data released in December 2018 provided evidence that ACH-4471 in combination with eculizumab had a positive impact on patient hemoglobin and FACIT-fatigue scores while reducing transfusions, reticulocyte counts and LDH levels. The company expects to present interim data for the first 10 patients on May 17, 2019 at The New Era of Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria meeting in Napoli, Italy. This specialized meeting is sponsored by AIEPEN Onlus, the Italian PNH Association.