Adynxx, Inc. announced On May 3, 2019, immediately prior to the Effective Time, David Johnson company Chief Executive Officer, resigned as an executive officer. On May 3, 2019, following the Effective Time of the Merger companyr board of directors appointed Rick Orr as company Chief Executive Officer (principal executive and financial officer), Donald Manning, M.D., Ph.D., as company Chief Medical Officer, and Julien Mamet, Ph.D. as company Chief Scientific Officer. There are no family relationships among any of company directors and executive officers. Biographical information regarding each of Mr. Orr, Dr. Manning and Dr. Mamet is included in company Definitive Proxy Statement on Schedule 14A, filed with the SEC on January 24, 2019, or the Proxy Statement, and is incorporated herein by reference.
Adynxx, Inc. is a clinical-stage biopharmaceutical company. The Company is focused on the development of a new class of therapeutics called transcription factor decoys and bringing to market disease-modifying products to address unmet needs in the treatment of pain and inflammation. The Company has leveraged its AYX platform of proprietary transcription factor decoys to identify and develop product candidates designed to modify the course of pain. Its product pipeline includes Brivoligide for postoperative pain and AYX2 for chronic pain. Brivoligide is a transcription factor decoy specifically designed to inhibit the function of transcription factor Early Growth Response 1 (EGR1), in the dorsal root ganglia (DRG), and spinal cord when administered at the time of surgery. Its second product candidate, AYX2, is a transcription factor decoy targeting the activity of specific members of the KLF family of transcription factors, including KLF6, KLF9 and KLF15.