Aimmune Therapeutics, Inc. presented results from longitudinal analyses evaluating immunological outcomes of long-term daily oral immunotherapy (OIT) with PALFORZIA? in patients with peanut allergy (PA) for up to 6 years, as well as new data on the utility benefits for Quality of Life (QoL) between pre- and post-OIT health states in children and adolescents with PA who received PALFORZIA and their caregivers in the United Kingdom (U.K.). PALFORZIA was approved as an oral immunotherapy (OIT) for the mitigation of allergic reactions, including anaphylaxis, that may occur with accidental exposure to peanut for patients aged 4 to 17 years with a confirmed diagnosis of peanut allergy on January 31, 2020 by the U.S. Food and Drug Administration (FDA), on December 17, 2020 by the European Commission (EC), on April 7, 2021 by the Medicines and Healthcare products Regulatory Agency (MHRA) in the U.K., and on May 4, 2021 by Swissmedic. Use of PALFORZIA may be continued in patients 18 years of age and older. PALFORZIA is not indicated for the emergency treatment of allergic reactions, including anaphylaxis and must always be used in conjunction with a peanut-avoidant diet. Data presented at the meeting suggest that continued long-term treatment (median treatment duration at the time of the data analysis was 3.21 years, with a maximum duration of 6 years) with PALFORZIA induced long-term immunomodulation, indicating a continued shift away from pretreatment sensitivity to peanut. Key highlights from this data presentation include: Median Peanut-Specific IgE levels (psIgE) declined initially in Year 2 from baseline, further lowering with continued treatment over time; The median Peanut-Specific IgG4 levels (psIgG4) increased to a peak around Years 2 and 3 from baseline; Additionally, median peanut Skin Prick Test (SPT) decreased over time hitting its lowest at Year 5 and plateauing in Year 6; Results indicate that median Peanut-Specific IgE to Peanut-Specific IgG4 Ratio (psIgE/psIgG4) declined substantially in Year 1 from baseline and remained lower up to Year 6. Additionally, results from a cross-sectional, observational study using different data collection methods, conducted in the U.K., provided the first-ever estimates of QoL utility measures for patients and caregivers across different health states relating to OIT in PA. The data showed a gain in utility related to QoL among patients treated with PALFORZIA and their caregivers between untreated PA and post-treated PA OIT health states.