Anatara Lifesciences Limited announced the successful completion of a challenge study in weaner piglets with its recently developed bromelain-based formulation (BONIFF). To address weaner piglet scour, which is estimated to cost the Australian pig industry more than $7 million per year1, Anatara and Ridley initiated a weaner piglet enterotoxigenic E. coli (ETEC) challenge study, utilising Anatara's bromelain-based formulation (BONIFF). The study was conducted by Murdoch University, with funding from the Australasian Pork Research Institute Ltd. The standard diet and the BONIFF-SMEC diets did not contain a pharmacological level of ZnO nor a commercial level of organic acid products (organic acids for manufacturing purposes only were added), whereas the SMEC diet alone (Treatment 5) contained commercially relevant levels of ZnO, organic acids and phytogenic compounds. In general, although indicating only a statistical trend (P > 0.2), pigs fed the BONIFF-SMEC diets and the SMEC (only) diet were heavier, by 6-11% respectively, at the end of the experiment compared to pigs fed the Standard diet, and not different to each other. This difference appeared to be caused by a significantly faster growth rate particularly in days 7-11 and days 12-13 after weaning that corresponded to a (numerically) higher daily feed intake in those periods. These periods coincided with the immediate time after ETEC inoculation and the change on day 11 to the common weaner diet, respectively. Intriguingly, days 7-11 was the period where pigs fed BONIFF-SMEC and SMEC diet alone (Treatment 5) generally showed more loose faeces and a higher diarrhoea index and received more medications. In these circumstances the product combination (in the case of BONIFF-SMEC) performance was not only able to be maintained but was greater than the Standard diet (i.e. not SMEC). For clarity, none of these diets contained commercially relevant levels of antimicrobial compounds. The growth performance data also demonstrated that pigs fed the BONIFF-SMEC diet performed equally, both with and without ETEC inoculation, to pigs fed the SMEC diet alone (Treatment 5) that comprised a pharmacological level of ZnO and levels of organic acids and phytogenics seen commercially, to assist in transitioning pigs in the post-weaning period. This suggests that at least under the conditions of this experiment, BONIFF could be considered as a replacement for these additives.