Apollomics Inc. announced a report by the Veneto Institute of Oncology on the efficacy response of a patient treated with vebreltinib for GBM with PTPRZ-MET fusion, at the European Society of Medical Oncology Congress (ESMO) 2023, held in Madrid, Spain from October 20-24, 2023. The patient with GBM with PTPRZ -MET fusion who had previously received radiotherapy and temozolomide, was reported to have an impressive Partial Response (PR) after 8 weeks of treatment with vebreltinib monotherapy during participation in the SPARTA study (NCT03175224). While the company is encouraged by the results, this information may not be indicative of efficacy in a larger GBM patient population.

GBM with MET fusion is an indication pursued by Apollomics and its China partner, Avistone Biotechnology. Avistone sponsors an active-controlled phase 2/3 study of vebreltinib for the treatment of GBM with PTPRZ--MET fusion, and has been in communication with the National Medical Products Administration (NMPA) regarding a supplemental New Drug Application (NDA) for this indication and has recently received priority review from the NMPA. Vebreltinib is a potent, small molecule, orally bioavailable and highly selective c-MET inhibitor.

Apollomics' lead programs include vebreltinib (APL-101), a potent, selective c-Met inhibitor for the treatment of non-small cell lung cancer and other advanced tumors with c-Met alterations, and uproleselan (APL-106), a specific E-Selectin antagonist that has the potential to be used adjunctively with standard chemotherapy to treat acute myeloid leukemia.